node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADCY3 | CA3 | ENSP00000260600 | ENSP00000285381 | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | carbonic anhydrase III, muscle specific; Reversible hydration of carbon dioxide | 0.723 |
ADCY3 | CAGE1 | ENSP00000260600 | ENSP00000425493 | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | cancer antigen 1 | 0.649 |
ADCY3 | GGT1 | ENSP00000260600 | ENSP00000248923 | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | gamma-glutamyltransferase 1; Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive | 0.847 |
ADCY3 | GGT2 | ENSP00000260600 | ENSP00000385721 | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | gamma-glutamyltransferase 2; Initiates extracellular glutathione (GSH) breakdown; catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors (By similarity) | 0.847 |
ADCY3 | TTC3 | ENSP00000260600 | ENSP00000346791 | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | tetratricopeptide repeat domain 3 | 0.537 |
CA3 | ADCY3 | ENSP00000285381 | ENSP00000260600 | carbonic anhydrase III, muscle specific; Reversible hydration of carbon dioxide | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | 0.723 |
CA3 | CAGE1 | ENSP00000285381 | ENSP00000425493 | carbonic anhydrase III, muscle specific; Reversible hydration of carbon dioxide | cancer antigen 1 | 0.631 |
CA3 | CCND1 | ENSP00000285381 | ENSP00000227507 | carbonic anhydrase III, muscle specific; Reversible hydration of carbon dioxide | cyclin D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate [...] | 0.817 |
CA3 | CYP24A1 | ENSP00000285381 | ENSP00000216862 | carbonic anhydrase III, muscle specific; Reversible hydration of carbon dioxide | cytochrome P450, family 24, subfamily A, polypeptide 1; Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25- hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23- hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product | 0.700 |
CA3 | GGT1 | ENSP00000285381 | ENSP00000248923 | carbonic anhydrase III, muscle specific; Reversible hydration of carbon dioxide | gamma-glutamyltransferase 1; Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive | 0.752 |
CA3 | GGT2 | ENSP00000285381 | ENSP00000385721 | carbonic anhydrase III, muscle specific; Reversible hydration of carbon dioxide | gamma-glutamyltransferase 2; Initiates extracellular glutathione (GSH) breakdown; catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors (By similarity) | 0.752 |
CA3 | INS | ENSP00000285381 | ENSP00000250971 | carbonic anhydrase III, muscle specific; Reversible hydration of carbon dioxide | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | 0.859 |
CA3 | LEP | ENSP00000285381 | ENSP00000312652 | carbonic anhydrase III, muscle specific; Reversible hydration of carbon dioxide | leptin; May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass | 0.821 |
CA3 | SRC | ENSP00000285381 | ENSP00000350941 | carbonic anhydrase III, muscle specific; Reversible hydration of carbon dioxide | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein- coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to f [...] | 0.644 |
CA3 | TTC3 | ENSP00000285381 | ENSP00000346791 | carbonic anhydrase III, muscle specific; Reversible hydration of carbon dioxide | tetratricopeptide repeat domain 3 | 0.679 |
CAGE1 | ADCY3 | ENSP00000425493 | ENSP00000260600 | cancer antigen 1 | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | 0.649 |
CAGE1 | CA3 | ENSP00000425493 | ENSP00000285381 | cancer antigen 1 | carbonic anhydrase III, muscle specific; Reversible hydration of carbon dioxide | 0.631 |
CAGE1 | GGT1 | ENSP00000425493 | ENSP00000248923 | cancer antigen 1 | gamma-glutamyltransferase 1; Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive | 0.870 |
CAGE1 | GGT2 | ENSP00000425493 | ENSP00000385721 | cancer antigen 1 | gamma-glutamyltransferase 2; Initiates extracellular glutathione (GSH) breakdown; catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors (By similarity) | 0.870 |
CAGE1 | INS | ENSP00000425493 | ENSP00000250971 | cancer antigen 1 | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | 0.414 |