node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARNTL | KLF10 | ENSP00000374357 | ENSP00000285407 | aryl hydrocarbon receptor nuclear translocator-like | Kruppel-like factor 10; Transcriptional repressor involved in the regulation of cell growth. Inhibits cell growth. Binds to the consensus sequence 5’-GGTGTG-3’ | 0.833 |
BMP2 | KLF10 | ENSP00000368104 | ENSP00000285407 | bone morphogenetic protein 2; Induces cartilage and bone formation | Kruppel-like factor 10; Transcriptional repressor involved in the regulation of cell growth. Inhibits cell growth. Binds to the consensus sequence 5’-GGTGTG-3’ | 0.850 |
BMP2 | SMAD7 | ENSP00000368104 | ENSP00000262158 | bone morphogenetic protein 2; Induces cartilage and bone formation | SMAD family member 7; Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A- PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator ( [...] | 0.994 |
BMP2 | TGFB1 | ENSP00000368104 | ENSP00000221930 | bone morphogenetic protein 2; Induces cartilage and bone formation | transforming growth factor, beta 1; Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts | 0.718 |
ITGAD | KLF10 | ENSP00000373854 | ENSP00000285407 | integrin, alpha D; Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood- borne pathogens, particulate matter, and senescent erythrocytes from the blood | Kruppel-like factor 10; Transcriptional repressor involved in the regulation of cell growth. Inhibits cell growth. Binds to the consensus sequence 5’-GGTGTG-3’ | 0.834 |
KDM5B | KLF10 | ENSP00000356234 | ENSP00000285407 | lysine (K)-specific demethylase 5B; Histone demethylase that demethylates ’Lys-4’ of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ’Lys-9’ or H3 ’Lys-27’. Demethylates trimethylated, dimethylated and monomethylated H3 ’Lys-4’. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma | Kruppel-like factor 10; Transcriptional repressor involved in the regulation of cell growth. Inhibits cell growth. Binds to the consensus sequence 5’-GGTGTG-3’ | 0.936 |
KLF10 | ARNTL | ENSP00000285407 | ENSP00000374357 | Kruppel-like factor 10; Transcriptional repressor involved in the regulation of cell growth. Inhibits cell growth. Binds to the consensus sequence 5’-GGTGTG-3’ | aryl hydrocarbon receptor nuclear translocator-like | 0.833 |
KLF10 | BMP2 | ENSP00000285407 | ENSP00000368104 | Kruppel-like factor 10; Transcriptional repressor involved in the regulation of cell growth. Inhibits cell growth. Binds to the consensus sequence 5’-GGTGTG-3’ | bone morphogenetic protein 2; Induces cartilage and bone formation | 0.850 |
KLF10 | ITGAD | ENSP00000285407 | ENSP00000373854 | Kruppel-like factor 10; Transcriptional repressor involved in the regulation of cell growth. Inhibits cell growth. Binds to the consensus sequence 5’-GGTGTG-3’ | integrin, alpha D; Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood- borne pathogens, particulate matter, and senescent erythrocytes from the blood | 0.834 |
KLF10 | KDM5B | ENSP00000285407 | ENSP00000356234 | Kruppel-like factor 10; Transcriptional repressor involved in the regulation of cell growth. Inhibits cell growth. Binds to the consensus sequence 5’-GGTGTG-3’ | lysine (K)-specific demethylase 5B; Histone demethylase that demethylates ’Lys-4’ of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ’Lys-9’ or H3 ’Lys-27’. Demethylates trimethylated, dimethylated and monomethylated H3 ’Lys-4’. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma | 0.936 |
KLF10 | PTGS1 | ENSP00000285407 | ENSP00000354612 | Kruppel-like factor 10; Transcriptional repressor involved in the regulation of cell growth. Inhibits cell growth. Binds to the consensus sequence 5’-GGTGTG-3’ | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase); May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells | 0.820 |
KLF10 | SIN3A | ENSP00000285407 | ENSP00000353622 | Kruppel-like factor 10; Transcriptional repressor involved in the regulation of cell growth. Inhibits cell growth. Binds to the consensus sequence 5’-GGTGTG-3’ | SIN3 transcription regulator homolog A (yeast); Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA (By similarity). Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation | 0.942 |
KLF10 | SMAD7 | ENSP00000285407 | ENSP00000262158 | Kruppel-like factor 10; Transcriptional repressor involved in the regulation of cell growth. Inhibits cell growth. Binds to the consensus sequence 5’-GGTGTG-3’ | SMAD family member 7; Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A- PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator ( [...] | 0.896 |
KLF10 | SP1 | ENSP00000285407 | ENSP00000329357 | Kruppel-like factor 10; Transcriptional repressor involved in the regulation of cell growth. Inhibits cell growth. Binds to the consensus sequence 5’-GGTGTG-3’ | Sp1 transcription factor; Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA d [...] | 0.824 |
KLF10 | TGFB1 | ENSP00000285407 | ENSP00000221930 | Kruppel-like factor 10; Transcriptional repressor involved in the regulation of cell growth. Inhibits cell growth. Binds to the consensus sequence 5’-GGTGTG-3’ | transforming growth factor, beta 1; Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts | 0.892 |
KLF10 | TYK2 | ENSP00000285407 | ENSP00000264818 | Kruppel-like factor 10; Transcriptional repressor involved in the regulation of cell growth. Inhibits cell growth. Binds to the consensus sequence 5’-GGTGTG-3’ | tyrosine kinase 2; Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain | 0.924 |
PTGS1 | KLF10 | ENSP00000354612 | ENSP00000285407 | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase); May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells | Kruppel-like factor 10; Transcriptional repressor involved in the regulation of cell growth. Inhibits cell growth. Binds to the consensus sequence 5’-GGTGTG-3’ | 0.820 |
SIN3A | KLF10 | ENSP00000353622 | ENSP00000285407 | SIN3 transcription regulator homolog A (yeast); Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA (By similarity). Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation | Kruppel-like factor 10; Transcriptional repressor involved in the regulation of cell growth. Inhibits cell growth. Binds to the consensus sequence 5’-GGTGTG-3’ | 0.942 |
SIN3A | SP1 | ENSP00000353622 | ENSP00000329357 | SIN3 transcription regulator homolog A (yeast); Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA (By similarity). Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation | Sp1 transcription factor; Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA d [...] | 0.727 |
SMAD7 | BMP2 | ENSP00000262158 | ENSP00000368104 | SMAD family member 7; Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A- PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator ( [...] | bone morphogenetic protein 2; Induces cartilage and bone formation | 0.994 |