node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARID5B | BBX | ENSP00000279873 | ENSP00000319974 | AT rich interactive domain 5B (MRF1-like) | bobby sox homolog (Drosophila); Transcription factor that is necessary for cell cycle progression from G1 to S phase | 0.558 |
ARID5B | C16orf87 | ENSP00000279873 | ENSP00000285697 | AT rich interactive domain 5B (MRF1-like) | chromosome 16 open reading frame 87 | 0.651 |
ARID5B | FAM60A | ENSP00000279873 | ENSP00000337477 | AT rich interactive domain 5B (MRF1-like) | family with sequence similarity 60, member A; Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of genes encoding components of the TGF-beta signaling pathway | 0.406 |
ARID5B | GEMIN4 | ENSP00000279873 | ENSP00000321706 | AT rich interactive domain 5B (MRF1-like) | gem (nuclear organelle) associated protein 4; The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus | 0.407 |
ARID5B | HDAC1 | ENSP00000279873 | ENSP00000362649 | AT rich interactive domain 5B (MRF1-like) | histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST- mediated transcription in resting neurons. Upon calcium s [...] | 0.650 |
ARID5B | HDAC2 | ENSP00000279873 | ENSP00000430432 | AT rich interactive domain 5B (MRF1-like) | histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed o [...] | 0.619 |
ARID5B | ZNF217 | ENSP00000279873 | ENSP00000304308 | AT rich interactive domain 5B (MRF1-like) | zinc finger protein 217; Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at ’Ser-473’ | 0.453 |
BBX | ARID5B | ENSP00000319974 | ENSP00000279873 | bobby sox homolog (Drosophila); Transcription factor that is necessary for cell cycle progression from G1 to S phase | AT rich interactive domain 5B (MRF1-like) | 0.558 |
BBX | C16orf87 | ENSP00000319974 | ENSP00000285697 | bobby sox homolog (Drosophila); Transcription factor that is necessary for cell cycle progression from G1 to S phase | chromosome 16 open reading frame 87 | 0.646 |
BBX | IKZF2 | ENSP00000319974 | ENSP00000410447 | bobby sox homolog (Drosophila); Transcription factor that is necessary for cell cycle progression from G1 to S phase | IKAROS family zinc finger 2 (Helios); Associates with Ikaros at centromeric heterochromatin | 0.412 |
BBX | ZNF215 | ENSP00000319974 | ENSP00000278319 | bobby sox homolog (Drosophila); Transcription factor that is necessary for cell cycle progression from G1 to S phase | zinc finger protein 215; May be involved in transcriptional regulation | 0.429 |
BBX | ZNF217 | ENSP00000319974 | ENSP00000304308 | bobby sox homolog (Drosophila); Transcription factor that is necessary for cell cycle progression from G1 to S phase | zinc finger protein 217; Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at ’Ser-473’ | 0.438 |
C16orf87 | ARID5B | ENSP00000285697 | ENSP00000279873 | chromosome 16 open reading frame 87 | AT rich interactive domain 5B (MRF1-like) | 0.651 |
C16orf87 | BBX | ENSP00000285697 | ENSP00000319974 | chromosome 16 open reading frame 87 | bobby sox homolog (Drosophila); Transcription factor that is necessary for cell cycle progression from G1 to S phase | 0.646 |
C16orf87 | FAM60A | ENSP00000285697 | ENSP00000337477 | chromosome 16 open reading frame 87 | family with sequence similarity 60, member A; Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of genes encoding components of the TGF-beta signaling pathway | 0.582 |
C16orf87 | GEMIN4 | ENSP00000285697 | ENSP00000321706 | chromosome 16 open reading frame 87 | gem (nuclear organelle) associated protein 4; The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus | 0.478 |
C16orf87 | HDAC1 | ENSP00000285697 | ENSP00000362649 | chromosome 16 open reading frame 87 | histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST- mediated transcription in resting neurons. Upon calcium s [...] | 0.615 |
C16orf87 | HDAC2 | ENSP00000285697 | ENSP00000430432 | chromosome 16 open reading frame 87 | histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed o [...] | 0.615 |
C16orf87 | IKZF2 | ENSP00000285697 | ENSP00000410447 | chromosome 16 open reading frame 87 | IKAROS family zinc finger 2 (Helios); Associates with Ikaros at centromeric heterochromatin | 0.471 |
C16orf87 | LINC00493 | ENSP00000285697 | ENSP00000466433 | chromosome 16 open reading frame 87 | long intergenic non-protein coding RNA 493 | 0.427 |