Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
KRT18 KRT18 MCM8 MCM8 CCDC146 CCDC146 ARHGAP23 ARHGAP23
"CCDC146" - coiled-coil domain containing 146 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CCDC146coiled-coil domain containing 146 (955 aa)    
Predicted Functional Partners:
ARHGAP23
Rho GTPase activating protein 23; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity) (1491 aa)
            score_image   0.632
KRT18
keratin 18; Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection (430 aa)
        score_image       0.580
MCM8
minichromosome maintenance complex component 8 (840 aa)
            score_image   0.568
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: medium (45%)