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CNOT10 CNOT10 CNOT6L CNOT6L BTG2 BTG2 PABPC1 PABPC1 CNOT1 CNOT1 CNOT4 CNOT4 CNOT8 CNOT8 CNOT2 CNOT2 CNOT6 CNOT6 RQCD1 RQCD1 BTG1 BTG1
"CNOT8" - CCR4-NOT transcription complex, subunit 8 in Homo sapiens
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CNOT8CCR4-NOT transcription complex, subunit 8; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be [...] (292 aa)    
Predicted Functional Partners:
CNOT1
CCR4-NOT transcription complex, subunit 1 (2376 aa)
      score_image score_image score_image score_image   0.999
CNOT6
CCR4-NOT transcription complex, subunit 6; Poly(A) nuclease with 3’-5’ RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein- coding determinant of instability (mCRD) of the FOS gene in the cyto [...] (557 aa)
        score_image score_image score_image   0.999
CNOT2
CCR4-NOT transcription complex, subunit 2; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may s [...] (540 aa)
        score_image score_image score_image   0.999
CNOT4
CCR4-NOT transcription complex, subunit 4 (713 aa)
      score_image score_image score_image score_image   0.999
CNOT6L
CCR4-NOT transcription complex, subunit 6-like; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3 [...] (555 aa)
        score_image score_image score_image   0.997
RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe); Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such a [...] (299 aa)
        score_image score_image score_image   0.994
CNOT10
CCR4-NOT transcription complex, subunit 10 (744 aa)
        score_image score_image score_image   0.977
BTG2
BTG family, member 2; Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenyltion in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors (By similarity). Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth (158 aa)
        score_image   score_image   0.976
PABPC1
poly(A) binding protein, cytoplasmic 1; Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre- mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability [...] (636 aa)
      score_image score_image score_image score_image   0.975
BTG1
B-cell translocation gene 1, anti-proliferative; Anti-proliferative protein (171 aa)
        score_image   score_image   0.971
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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