node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BTG1 | CNOT8 | ENSP00000256015 | ENSP00000285896 | B-cell translocation gene 1, anti-proliferative; Anti-proliferative protein | CCR4-NOT transcription complex, subunit 8; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be [...] | 0.971 |
BTG2 | CNOT1 | ENSP00000290551 | ENSP00000320949 | BTG family, member 2; Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenyltion in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors (By similarity). Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth | CCR4-NOT transcription complex, subunit 1 | 0.490 |
BTG2 | CNOT6L | ENSP00000290551 | ENSP00000264903 | BTG family, member 2; Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenyltion in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors (By similarity). Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth | CCR4-NOT transcription complex, subunit 6-like; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3 [...] | 0.639 |
BTG2 | CNOT8 | ENSP00000290551 | ENSP00000285896 | BTG family, member 2; Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenyltion in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors (By similarity). Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth | CCR4-NOT transcription complex, subunit 8; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be [...] | 0.976 |
CNOT1 | BTG2 | ENSP00000320949 | ENSP00000290551 | CCR4-NOT transcription complex, subunit 1 | BTG family, member 2; Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenyltion in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors (By similarity). Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth | 0.490 |
CNOT1 | CNOT10 | ENSP00000320949 | ENSP00000330060 | CCR4-NOT transcription complex, subunit 1 | CCR4-NOT transcription complex, subunit 10 | 0.945 |
CNOT1 | CNOT2 | ENSP00000320949 | ENSP00000229195 | CCR4-NOT transcription complex, subunit 1 | CCR4-NOT transcription complex, subunit 2; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may s [...] | 0.999 |
CNOT1 | CNOT4 | ENSP00000320949 | ENSP00000445508 | CCR4-NOT transcription complex, subunit 1 | CCR4-NOT transcription complex, subunit 4 | 0.999 |
CNOT1 | CNOT6 | ENSP00000320949 | ENSP00000261951 | CCR4-NOT transcription complex, subunit 1 | CCR4-NOT transcription complex, subunit 6; Poly(A) nuclease with 3’-5’ RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein- coding determinant of instability (mCRD) of the FOS gene in the cyto [...] | 0.998 |
CNOT1 | CNOT6L | ENSP00000320949 | ENSP00000264903 | CCR4-NOT transcription complex, subunit 1 | CCR4-NOT transcription complex, subunit 6-like; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3 [...] | 0.999 |
CNOT1 | CNOT8 | ENSP00000320949 | ENSP00000285896 | CCR4-NOT transcription complex, subunit 1 | CCR4-NOT transcription complex, subunit 8; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be [...] | 0.999 |
CNOT1 | PABPC1 | ENSP00000320949 | ENSP00000313007 | CCR4-NOT transcription complex, subunit 1 | poly(A) binding protein, cytoplasmic 1; Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre- mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability [...] | 0.944 |
CNOT1 | RQCD1 | ENSP00000320949 | ENSP00000273064 | CCR4-NOT transcription complex, subunit 1 | RCD1 required for cell differentiation1 homolog (S. pombe); Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such a [...] | 0.999 |
CNOT10 | CNOT1 | ENSP00000330060 | ENSP00000320949 | CCR4-NOT transcription complex, subunit 10 | CCR4-NOT transcription complex, subunit 1 | 0.945 |
CNOT10 | CNOT2 | ENSP00000330060 | ENSP00000229195 | CCR4-NOT transcription complex, subunit 10 | CCR4-NOT transcription complex, subunit 2; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may s [...] | 0.976 |
CNOT10 | CNOT4 | ENSP00000330060 | ENSP00000445508 | CCR4-NOT transcription complex, subunit 10 | CCR4-NOT transcription complex, subunit 4 | 0.968 |
CNOT10 | CNOT6 | ENSP00000330060 | ENSP00000261951 | CCR4-NOT transcription complex, subunit 10 | CCR4-NOT transcription complex, subunit 6; Poly(A) nuclease with 3’-5’ RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein- coding determinant of instability (mCRD) of the FOS gene in the cyto [...] | 0.962 |
CNOT10 | CNOT6L | ENSP00000330060 | ENSP00000264903 | CCR4-NOT transcription complex, subunit 10 | CCR4-NOT transcription complex, subunit 6-like; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3 [...] | 0.972 |
CNOT10 | CNOT8 | ENSP00000330060 | ENSP00000285896 | CCR4-NOT transcription complex, subunit 10 | CCR4-NOT transcription complex, subunit 8; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be [...] | 0.977 |
CNOT10 | PABPC1 | ENSP00000330060 | ENSP00000313007 | CCR4-NOT transcription complex, subunit 10 | poly(A) binding protein, cytoplasmic 1; Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre- mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability [...] | 0.904 |