node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C1orf112 | GINS1 | ENSP00000286031 | ENSP00000262460 | chromosome 1 open reading frame 112 | GINS complex subunit 1 (Psf1 homolog); The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single- stranded DNA. GINS1 is essential for function | 0.777 |
C1orf112 | GINS2 | ENSP00000286031 | ENSP00000253462 | chromosome 1 open reading frame 112 | GINS complex subunit 2 (Psf2 homolog); The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single- stranded DNA | 0.427 |
C1orf112 | KIF15 | ENSP00000286031 | ENSP00000324020 | chromosome 1 open reading frame 112 | kinesin family member 15; Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly (By similarity) | 0.418 |
C1orf112 | MAP7D1 | ENSP00000286031 | ENSP00000362244 | chromosome 1 open reading frame 112 | MAP7 domain containing 1 | 0.803 |
C1orf112 | MTERFD1 | ENSP00000286031 | ENSP00000287025 | chromosome 1 open reading frame 112 | MTERF domain containing 1; Binds promoter DNA and regulates initiation of transcription. Required for normal mitochondrial transcription, and for normal assembly of mitochondrial respiratory complexes. Required for normal mitochondrial function (By similarity) | 0.771 |
C1orf112 | PSMC3IP | ENSP00000286031 | ENSP00000377384 | chromosome 1 open reading frame 112 | PSMC3 interacting protein; Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1- promoted homologous pairing. May inhibit HIV-1 viral protein TAT activ [...] | 0.509 |
C1orf112 | TMSB15B | ENSP00000286031 | ENSP00000457601 | chromosome 1 open reading frame 112 | thymosin beta 15B; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity). May be involved in cell migration | 0.506 |
C1orf112 | UBC | ENSP00000286031 | ENSP00000344818 | chromosome 1 open reading frame 112 | ubiquitin C | 0.483 |
GINS1 | C1orf112 | ENSP00000262460 | ENSP00000286031 | GINS complex subunit 1 (Psf1 homolog); The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single- stranded DNA. GINS1 is essential for function | chromosome 1 open reading frame 112 | 0.777 |
GINS1 | GINS2 | ENSP00000262460 | ENSP00000253462 | GINS complex subunit 1 (Psf1 homolog); The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single- stranded DNA. GINS1 is essential for function | GINS complex subunit 2 (Psf2 homolog); The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single- stranded DNA | 0.999 |
GINS1 | MAP7D1 | ENSP00000262460 | ENSP00000362244 | GINS complex subunit 1 (Psf1 homolog); The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single- stranded DNA. GINS1 is essential for function | MAP7 domain containing 1 | 0.689 |
GINS1 | MTERFD1 | ENSP00000262460 | ENSP00000287025 | GINS complex subunit 1 (Psf1 homolog); The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single- stranded DNA. GINS1 is essential for function | MTERF domain containing 1; Binds promoter DNA and regulates initiation of transcription. Required for normal mitochondrial transcription, and for normal assembly of mitochondrial respiratory complexes. Required for normal mitochondrial function (By similarity) | 0.664 |
GINS1 | PSMC3IP | ENSP00000262460 | ENSP00000377384 | GINS complex subunit 1 (Psf1 homolog); The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single- stranded DNA. GINS1 is essential for function | PSMC3 interacting protein; Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1- promoted homologous pairing. May inhibit HIV-1 viral protein TAT activ [...] | 0.533 |
GINS1 | UBC | ENSP00000262460 | ENSP00000344818 | GINS complex subunit 1 (Psf1 homolog); The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single- stranded DNA. GINS1 is essential for function | ubiquitin C | 0.854 |
GINS2 | C1orf112 | ENSP00000253462 | ENSP00000286031 | GINS complex subunit 2 (Psf2 homolog); The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single- stranded DNA | chromosome 1 open reading frame 112 | 0.427 |
GINS2 | GINS1 | ENSP00000253462 | ENSP00000262460 | GINS complex subunit 2 (Psf2 homolog); The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single- stranded DNA | GINS complex subunit 1 (Psf1 homolog); The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single- stranded DNA. GINS1 is essential for function | 0.999 |
GINS2 | UBC | ENSP00000253462 | ENSP00000344818 | GINS complex subunit 2 (Psf2 homolog); The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single- stranded DNA | ubiquitin C | 0.875 |
KIF15 | C1orf112 | ENSP00000324020 | ENSP00000286031 | kinesin family member 15; Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly (By similarity) | chromosome 1 open reading frame 112 | 0.418 |
KIF15 | UBC | ENSP00000324020 | ENSP00000344818 | kinesin family member 15; Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly (By similarity) | ubiquitin C | 0.541 |
MAP7D1 | C1orf112 | ENSP00000362244 | ENSP00000286031 | MAP7 domain containing 1 | chromosome 1 open reading frame 112 | 0.803 |