node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AEBP2 | C10orf12 | ENSP00000381840 | ENSP00000286067 | AE binding protein 2; DNA-binding transcriptional repressor. May interact with and stimulate the activity of the PRC2 complex, which methylates ’Lys-9’ and ’Lys-27’ residues of histone H3 | chromosome 10 open reading frame 12 | 0.503 |
AEBP2 | C17orf96 | ENSP00000381840 | ENSP00000317905 | AE binding protein 2; DNA-binding transcriptional repressor. May interact with and stimulate the activity of the PRC2 complex, which methylates ’Lys-9’ and ’Lys-27’ residues of histone H3 | chromosome 17 open reading frame 96 | 0.457 |
AEBP2 | EHMT2 | ENSP00000381840 | ENSP00000364687 | AE binding protein 2; DNA-binding transcriptional repressor. May interact with and stimulate the activity of the PRC2 complex, which methylates ’Lys-9’ and ’Lys-27’ residues of histone H3 | euchromatic histone-lysine N-methyltransferase 2 | 0.535 |
AEBP2 | EZH2 | ENSP00000381840 | ENSP00000320147 | AE binding protein 2; DNA-binding transcriptional repressor. May interact with and stimulate the activity of the PRC2 complex, which methylates ’Lys-9’ and ’Lys-27’ residues of histone H3 | enhancer of zeste homolog 2 (Drosophila) | 0.981 |
AEBP2 | MTF2 | ENSP00000381840 | ENSP00000359321 | AE binding protein 2; DNA-binding transcriptional repressor. May interact with and stimulate the activity of the PRC2 complex, which methylates ’Lys-9’ and ’Lys-27’ residues of histone H3 | metal response element binding transcription factor 2; Polycomb group (PcG) that specifically binds histone H3 trimethylated at ’Lys-36’ (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated [...] | 0.677 |
AEBP2 | SUZ12 | ENSP00000381840 | ENSP00000316578 | AE binding protein 2; DNA-binding transcriptional repressor. May interact with and stimulate the activity of the PRC2 complex, which methylates ’Lys-9’ and ’Lys-27’ residues of histone H3 | suppressor of zeste 12 homolog (Drosophila); Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates ’Lys-9’ (H3K9me) and ’Lys-27’ (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A | 0.995 |
C10orf12 | AEBP2 | ENSP00000286067 | ENSP00000381840 | chromosome 10 open reading frame 12 | AE binding protein 2; DNA-binding transcriptional repressor. May interact with and stimulate the activity of the PRC2 complex, which methylates ’Lys-9’ and ’Lys-27’ residues of histone H3 | 0.503 |
C10orf12 | C17orf96 | ENSP00000286067 | ENSP00000317905 | chromosome 10 open reading frame 12 | chromosome 17 open reading frame 96 | 0.754 |
C10orf12 | EHMT2 | ENSP00000286067 | ENSP00000364687 | chromosome 10 open reading frame 12 | euchromatic histone-lysine N-methyltransferase 2 | 0.698 |
C10orf12 | EZH2 | ENSP00000286067 | ENSP00000320147 | chromosome 10 open reading frame 12 | enhancer of zeste homolog 2 (Drosophila) | 0.432 |
C10orf12 | LCOR | ENSP00000286067 | ENSP00000348298 | chromosome 10 open reading frame 12 | ligand dependent nuclear receptor corepressor; May act as transcription activator that binds DNA elements with the sequence 5’-CCCTATCGATCGATCTCTACCT-3’ (By similarity). Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand- dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR | 0.493 |
C10orf12 | LCORL | ENSP00000286067 | ENSP00000371661 | chromosome 10 open reading frame 12 | ligand dependent nuclear receptor corepressor-like; May act as transcription activator that binds DNA elements with the sequence 5’-CCCTATCGATCGATCTCTACCT-3’. May play a role in spermatogenesis (By similarity) | 0.602 |
C10orf12 | MTF2 | ENSP00000286067 | ENSP00000359321 | chromosome 10 open reading frame 12 | metal response element binding transcription factor 2; Polycomb group (PcG) that specifically binds histone H3 trimethylated at ’Lys-36’ (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated [...] | 0.456 |
C10orf12 | SUZ12 | ENSP00000286067 | ENSP00000316578 | chromosome 10 open reading frame 12 | suppressor of zeste 12 homolog (Drosophila); Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates ’Lys-9’ (H3K9me) and ’Lys-27’ (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A | 0.493 |
C17orf96 | AEBP2 | ENSP00000317905 | ENSP00000381840 | chromosome 17 open reading frame 96 | AE binding protein 2; DNA-binding transcriptional repressor. May interact with and stimulate the activity of the PRC2 complex, which methylates ’Lys-9’ and ’Lys-27’ residues of histone H3 | 0.457 |
C17orf96 | C10orf12 | ENSP00000317905 | ENSP00000286067 | chromosome 17 open reading frame 96 | chromosome 10 open reading frame 12 | 0.754 |
C17orf96 | MTF2 | ENSP00000317905 | ENSP00000359321 | chromosome 17 open reading frame 96 | metal response element binding transcription factor 2; Polycomb group (PcG) that specifically binds histone H3 trimethylated at ’Lys-36’ (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated [...] | 0.610 |
C17orf96 | SUZ12 | ENSP00000317905 | ENSP00000316578 | chromosome 17 open reading frame 96 | suppressor of zeste 12 homolog (Drosophila); Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates ’Lys-9’ (H3K9me) and ’Lys-27’ (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A | 0.511 |
EHMT2 | AEBP2 | ENSP00000364687 | ENSP00000381840 | euchromatic histone-lysine N-methyltransferase 2 | AE binding protein 2; DNA-binding transcriptional repressor. May interact with and stimulate the activity of the PRC2 complex, which methylates ’Lys-9’ and ’Lys-27’ residues of histone H3 | 0.535 |
EHMT2 | C10orf12 | ENSP00000364687 | ENSP00000286067 | euchromatic histone-lysine N-methyltransferase 2 | chromosome 10 open reading frame 12 | 0.698 |