node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KEAP1 | RBM45 | ENSP00000171111 | ENSP00000286070 | kelch-like ECH-associated protein 1; Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome | RNA binding motif protein 45; RNA-binding protein with binding specificity for poly(C). May play an important role in neural development | 0.534 |
MEMO1 | RBM45 | ENSP00000295065 | ENSP00000286070 | mediator of cell motility 1; May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell mi [...] | RNA binding motif protein 45; RNA-binding protein with binding specificity for poly(C). May play an important role in neural development | 0.549 |
METTL5 | RBM45 | ENSP00000260953 | ENSP00000286070 | methyltransferase like 5; Probable methyltransferase (By similarity) | RNA binding motif protein 45; RNA-binding protein with binding specificity for poly(C). May play an important role in neural development | 0.450 |
NES | RBFOX3 | ENSP00000357206 | ENSP00000393262 | nestin; Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity) | RNA binding protein, fox-1 homolog (C. elegans) 3; RNA-binding protein that regulates alternative splicing events (By similarity) | 0.816 |
NES | RBM45 | ENSP00000357206 | ENSP00000286070 | nestin; Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity) | RNA binding motif protein 45; RNA-binding protein with binding specificity for poly(C). May play an important role in neural development | 0.749 |
RBFOX3 | NES | ENSP00000393262 | ENSP00000357206 | RNA binding protein, fox-1 homolog (C. elegans) 3; RNA-binding protein that regulates alternative splicing events (By similarity) | nestin; Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity) | 0.816 |
RBFOX3 | RBM45 | ENSP00000393262 | ENSP00000286070 | RNA binding protein, fox-1 homolog (C. elegans) 3; RNA-binding protein that regulates alternative splicing events (By similarity) | RNA binding motif protein 45; RNA-binding protein with binding specificity for poly(C). May play an important role in neural development | 0.741 |
RBM45 | KEAP1 | ENSP00000286070 | ENSP00000171111 | RNA binding motif protein 45; RNA-binding protein with binding specificity for poly(C). May play an important role in neural development | kelch-like ECH-associated protein 1; Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome | 0.534 |
RBM45 | MEMO1 | ENSP00000286070 | ENSP00000295065 | RNA binding motif protein 45; RNA-binding protein with binding specificity for poly(C). May play an important role in neural development | mediator of cell motility 1; May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell mi [...] | 0.549 |
RBM45 | METTL5 | ENSP00000286070 | ENSP00000260953 | RNA binding motif protein 45; RNA-binding protein with binding specificity for poly(C). May play an important role in neural development | methyltransferase like 5; Probable methyltransferase (By similarity) | 0.450 |
RBM45 | NES | ENSP00000286070 | ENSP00000357206 | RNA binding motif protein 45; RNA-binding protein with binding specificity for poly(C). May play an important role in neural development | nestin; Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity) | 0.749 |
RBM45 | RBFOX3 | ENSP00000286070 | ENSP00000393262 | RNA binding motif protein 45; RNA-binding protein with binding specificity for poly(C). May play an important role in neural development | RNA binding protein, fox-1 homolog (C. elegans) 3; RNA-binding protein that regulates alternative splicing events (By similarity) | 0.741 |
RBM45 | TARDBP | ENSP00000286070 | ENSP00000240185 | RNA binding motif protein 45; RNA-binding protein with binding specificity for poly(C). May play an important role in neural development | TAR DNA binding protein | 0.647 |
RBM45 | UPK3A | ENSP00000286070 | ENSP00000216211 | RNA binding motif protein 45; RNA-binding protein with binding specificity for poly(C). May play an important role in neural development | uroplakin 3A; Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity) | 0.452 |
RBM45 | USP16 | ENSP00000286070 | ENSP00000334808 | RNA binding motif protein 45; RNA-binding protein with binding specificity for poly(C). May play an important role in neural development | ubiquitin specific peptidase 16 | 0.684 |
RBM45 | USP21 | ENSP00000286070 | ENSP00000289865 | RNA binding motif protein 45; RNA-binding protein with binding specificity for poly(C). May play an important role in neural development | ubiquitin specific peptidase 21; Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at ’Lys-4’, resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates | 0.572 |
RBM45 | ZNF691 | ENSP00000286070 | ENSP00000380237 | RNA binding motif protein 45; RNA-binding protein with binding specificity for poly(C). May play an important role in neural development | zinc finger protein 691; May be involved in transcriptional regulation | 0.472 |
TARDBP | RBM45 | ENSP00000240185 | ENSP00000286070 | TAR DNA binding protein | RNA binding motif protein 45; RNA-binding protein with binding specificity for poly(C). May play an important role in neural development | 0.647 |
UPK3A | RBM45 | ENSP00000216211 | ENSP00000286070 | uroplakin 3A; Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity) | RNA binding motif protein 45; RNA-binding protein with binding specificity for poly(C). May play an important role in neural development | 0.452 |
USP16 | RBM45 | ENSP00000334808 | ENSP00000286070 | ubiquitin specific peptidase 16 | RNA binding motif protein 45; RNA-binding protein with binding specificity for poly(C). May play an important role in neural development | 0.684 |