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STRINGSTRING
NES NES RBFOX3 RBFOX3 ZNF691 ZNF691 MEMO1 MEMO1 UPK3A UPK3A RBM45 RBM45 KEAP1 KEAP1 TARDBP TARDBP USP16 USP16 USP21 USP21 METTL5 METTL5
"RBM45" - RNA binding motif protein 45 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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experimentally determined
Predicted Interactions
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fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining
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protein homology
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Score
RBM45RNA binding motif protein 45; RNA-binding protein with binding specificity for poly(C). May play an important role in neural development (474 aa)    
Predicted Functional Partners:
NES
nestin; Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity) (1621 aa)
            score_image   0.749
RBFOX3
RNA binding protein, fox-1 homolog (C. elegans) 3; RNA-binding protein that regulates alternative splicing events (By similarity) (312 aa)
            score_image   0.741
USP16
ubiquitin specific peptidase 16 (823 aa)
        score_image       0.684
TARDBP
TAR DNA binding protein (414 aa)
        score_image   score_image   0.647
USP21
ubiquitin specific peptidase 21; Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at ’Lys-4’, resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates (565 aa)
        score_image       0.572
MEMO1
mediator of cell motility 1; May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell mi [...] (297 aa)
        score_image       0.549
KEAP1
kelch-like ECH-associated protein 1; Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (624 aa)
        score_image       0.534
ZNF691
zinc finger protein 691; May be involved in transcriptional regulation (315 aa)
            score_image   0.472
UPK3A
uroplakin 3A; Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity) (287 aa)
            score_image   0.452
METTL5
methyltransferase like 5; Probable methyltransferase (By similarity) (209 aa)
            score_image   0.450
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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