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TRIP11 TRIP11 SLC13A2 SLC13A2 MATN3 MATN3 GPC6 GPC6 CANT1 CANT1 SLC26A2 SLC26A2 PAPSS2 PAPSS2 FOXI1 FOXI1 PAPSS1 PAPSS1 SLC13A3 SLC13A3 SLC13A4 SLC13A4
"SLC26A2" - solute carrier family 26 (sulfate transporter), member 2 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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second shell of interactors
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Predicted Interactions
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protein homology
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SLC26A2solute carrier family 26 (sulfate transporter), member 2; Sulfate transporter. May play a role in endochondral bone formation (739 aa)    
Predicted Functional Partners:
PAPSS2
3’-phosphoadenosine 5’-phosphosulfate synthase 2; Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5’-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3’-phosphoadenylylsulfate (PAPS- activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. May have a important [...] (619 aa)
       score_image   score_image score_image   0.982
PAPSS1
3’-phosphoadenosine 5’-phosphosulfate synthase 1; Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5’-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3’-phosphoadenylylsulfate (PAPS- activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. Also involved in the [...] (624 aa)
       score_image   score_image score_image   0.978
MATN3
matrilin 3; Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks (486 aa)
             score_image   0.757
GPC6
glypican 6; Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases (By similarity). Enhances migration and invasion of cancer cells through WNT5A signaling (555 aa)
             score_image   0.744
TRIP11
thyroid hormone receptor interactor 11; Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB- modulated transcription. Golgi auto-antigen; probably involved in maintaining cis-Golgi structure (1979 aa)
             score_image   0.742
FOXI1
forkhead box I1; Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules (By similarity) (378 aa)
             score_image   0.720
SLC13A4
solute carrier family 13 (sodium/sulfate symporters), member 4; Sodium/sulfate cotransporter that mediates sulfate reabsorption in the high endothelial venules (HEV) (626 aa)
             score_image   0.716
SLC13A2
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2; Cotransport of sodium ions and dicarboxylates such as succinate and citrate (641 aa)
             score_image   0.698
SLC13A3
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 (602 aa)
             score_image   0.694
CANT1
calcium activated nucleotidase 1; Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis (401 aa)
             score_image   0.682
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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