| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ASIC1 | ASIC2 | ENSP00000228468 | ENSP00000225823 | acid-sensing (proton-gated) ion channel 1; Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Ca(2+), Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor th [...] | acid-sensing (proton-gated) ion channel 2; Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate | 0.594 |
| ASIC1 | STOM | ENSP00000228468 | ENSP00000286713 | acid-sensing (proton-gated) ion channel 1; Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Ca(2+), Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor th [...] | stomatin; Thought to regulate cation conductance. May regulate ASIC2 and ASIC3 gating (By similarity) | 0.938 |
| ASIC2 | ASIC1 | ENSP00000225823 | ENSP00000228468 | acid-sensing (proton-gated) ion channel 2; Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate | acid-sensing (proton-gated) ion channel 1; Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Ca(2+), Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor th [...] | 0.594 |
| ASIC2 | ASIC3 | ENSP00000225823 | ENSP00000297512 | acid-sensing (proton-gated) ion channel 2; Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate | acid-sensing (proton-gated) ion channel 3; Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties | 0.601 |
| ASIC2 | STOM | ENSP00000225823 | ENSP00000286713 | acid-sensing (proton-gated) ion channel 2; Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate | stomatin; Thought to regulate cation conductance. May regulate ASIC2 and ASIC3 gating (By similarity) | 0.884 |
| ASIC3 | ASIC2 | ENSP00000297512 | ENSP00000225823 | acid-sensing (proton-gated) ion channel 3; Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties | acid-sensing (proton-gated) ion channel 2; Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate | 0.601 |
| ASIC3 | PIEZO1 | ENSP00000297512 | ENSP00000301015 | acid-sensing (proton-gated) ion channel 3; Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties | piezo-type mechanosensitive ion channel component 1; Component of mechanosensitive channel required for the mechanosensitive currents. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling | 0.419 |
| ASIC3 | STOM | ENSP00000297512 | ENSP00000286713 | acid-sensing (proton-gated) ion channel 3; Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties | stomatin; Thought to regulate cation conductance. May regulate ASIC2 and ASIC3 gating (By similarity) | 0.956 |
| LANCL1 | STOM | ENSP00000233714 | ENSP00000286713 | LanC lantibiotic synthetase component C-like 1 (bacterial); May play a role in EPS8 signaling. Binds glutathion | stomatin; Thought to regulate cation conductance. May regulate ASIC2 and ASIC3 gating (By similarity) | 0.890 |
| LANCL1 | UBC | ENSP00000233714 | ENSP00000344818 | LanC lantibiotic synthetase component C-like 1 (bacterial); May play a role in EPS8 signaling. Binds glutathion | ubiquitin C | 0.897 |
| MT-ND1 | STOM | ENSP00000354687 | ENSP00000286713 | mitochondrially encoded NADH dehydrogenase 1; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity) | stomatin; Thought to regulate cation conductance. May regulate ASIC2 and ASIC3 gating (By similarity) | 0.793 |
| PIEZO1 | ASIC3 | ENSP00000301015 | ENSP00000297512 | piezo-type mechanosensitive ion channel component 1; Component of mechanosensitive channel required for the mechanosensitive currents. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling | acid-sensing (proton-gated) ion channel 3; Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties | 0.419 |
| PIEZO1 | RHAG | ENSP00000301015 | ENSP00000360217 | piezo-type mechanosensitive ion channel component 1; Component of mechanosensitive channel required for the mechanosensitive currents. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling | Rh-associated glycoprotein; Associated with rhesus blood group antigen expression. May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane | 0.801 |
| PIEZO1 | STOM | ENSP00000301015 | ENSP00000286713 | piezo-type mechanosensitive ion channel component 1; Component of mechanosensitive channel required for the mechanosensitive currents. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling | stomatin; Thought to regulate cation conductance. May regulate ASIC2 and ASIC3 gating (By similarity) | 0.811 |
| PIEZO1 | UBC | ENSP00000301015 | ENSP00000344818 | piezo-type mechanosensitive ion channel component 1; Component of mechanosensitive channel required for the mechanosensitive currents. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling | ubiquitin C | 0.795 |
| RHAG | PIEZO1 | ENSP00000360217 | ENSP00000301015 | Rh-associated glycoprotein; Associated with rhesus blood group antigen expression. May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane | piezo-type mechanosensitive ion channel component 1; Component of mechanosensitive channel required for the mechanosensitive currents. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling | 0.801 |
| RHAG | SLC2A1 | ENSP00000360217 | ENSP00000416293 | Rh-associated glycoprotein; Associated with rhesus blood group antigen expression. May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane | solute carrier family 2 (facilitated glucose transporter), member 1; Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses | 0.459 |
| RHAG | STOM | ENSP00000360217 | ENSP00000286713 | Rh-associated glycoprotein; Associated with rhesus blood group antigen expression. May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane | stomatin; Thought to regulate cation conductance. May regulate ASIC2 and ASIC3 gating (By similarity) | 0.860 |
| SLC2A1 | RHAG | ENSP00000416293 | ENSP00000360217 | solute carrier family 2 (facilitated glucose transporter), member 1; Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses | Rh-associated glycoprotein; Associated with rhesus blood group antigen expression. May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane | 0.459 |
| SLC2A1 | STOM | ENSP00000416293 | ENSP00000286713 | solute carrier family 2 (facilitated glucose transporter), member 1; Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses | stomatin; Thought to regulate cation conductance. May regulate ASIC2 and ASIC3 gating (By similarity) | 0.784 |
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