NAA11 protein (Homo sapiens) - STRING network view

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NAA11

N(alpha)-acetyltransferase 11, NatA catalytic subunit; In complex with NAA15, displays alpha (N-terminal) acetyltransferase activity (229 aa)

Predicted Functional Partners:

NAA15

0.996

NAA16

0.990

NAA35

0.965

NAA30

0.922

LSMD1

0.910

UBC

0.819

NAA25

0.757

NAA10

0.723

HYPK

0.679

HIF1A

0.603

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HIF1A	NAA10	ENSP00000338018	ENSP00000417763	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to [...]	N(alpha)-acetyltransferase 10, NatA catalytic subunit; In complex with NAA15, displays alpha (N-terminal) acetyltransferase activity. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration	0.576
HIF1A	NAA11	ENSP00000338018	ENSP00000286794	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to [...]	N(alpha)-acetyltransferase 11, NatA catalytic subunit; In complex with NAA15, displays alpha (N-terminal) acetyltransferase activity	0.603
HIF1A	UBC	ENSP00000338018	ENSP00000344818	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to [...]	ubiquitin C	0.999
HYPK	NAA10	ENSP00000384474	ENSP00000417763	huntingtin interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10- NAA15 complex-mediated N-terminal acetylation	N(alpha)-acetyltransferase 10, NatA catalytic subunit; In complex with NAA15, displays alpha (N-terminal) acetyltransferase activity. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration	0.765
HYPK	NAA11	ENSP00000384474	ENSP00000286794	huntingtin interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10- NAA15 complex-mediated N-terminal acetylation	N(alpha)-acetyltransferase 11, NatA catalytic subunit; In complex with NAA15, displays alpha (N-terminal) acetyltransferase activity	0.679
HYPK	NAA15	ENSP00000384474	ENSP00000296543	huntingtin interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10- NAA15 complex-mediated N-terminal acetylation	N(alpha)-acetyltransferase 15, NatA auxiliary subunit; The NAA10-NAA15 complex displays alpha (N-terminal) acetyltransferase activity that may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter	0.967
HYPK	NAA16	ENSP00000384474	ENSP00000368716	huntingtin interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10- NAA15 complex-mediated N-terminal acetylation	N(alpha)-acetyltransferase 16, NatA auxiliary subunit; May belong to a complex displaying N-terminal acetyltransferase activity (By similarity)	0.901
HYPK	NAA30	ENSP00000384474	ENSP00000452521	huntingtin interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10- NAA15 complex-mediated N-terminal acetylation	N(alpha)-acetyltransferase 30, NatC catalytic subunit; Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex. Catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly. Necessary for the lysosomal localization and function of ARL8B	0.466
LSMD1	NAA10	ENSP00000332103	ENSP00000417763	LSM domain containing 1; Component of the N-terminal acetyltransferase C (NatC) complex which may catalyze acetylation of N-terminal methionine residues	N(alpha)-acetyltransferase 10, NatA catalytic subunit; In complex with NAA15, displays alpha (N-terminal) acetyltransferase activity. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration	0.720
LSMD1	NAA11	ENSP00000332103	ENSP00000286794	LSM domain containing 1; Component of the N-terminal acetyltransferase C (NatC) complex which may catalyze acetylation of N-terminal methionine residues	N(alpha)-acetyltransferase 11, NatA catalytic subunit; In complex with NAA15, displays alpha (N-terminal) acetyltransferase activity	0.910
LSMD1	NAA15	ENSP00000332103	ENSP00000296543	LSM domain containing 1; Component of the N-terminal acetyltransferase C (NatC) complex which may catalyze acetylation of N-terminal methionine residues	N(alpha)-acetyltransferase 15, NatA auxiliary subunit; The NAA10-NAA15 complex displays alpha (N-terminal) acetyltransferase activity that may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter	0.901
LSMD1	NAA16	ENSP00000332103	ENSP00000368716	LSM domain containing 1; Component of the N-terminal acetyltransferase C (NatC) complex which may catalyze acetylation of N-terminal methionine residues	N(alpha)-acetyltransferase 16, NatA auxiliary subunit; May belong to a complex displaying N-terminal acetyltransferase activity (By similarity)	0.749
LSMD1	NAA30	ENSP00000332103	ENSP00000452521	LSM domain containing 1; Component of the N-terminal acetyltransferase C (NatC) complex which may catalyze acetylation of N-terminal methionine residues	N(alpha)-acetyltransferase 30, NatC catalytic subunit; Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex. Catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly. Necessary for the lysosomal localization and function of ARL8B	0.968
LSMD1	NAA35	ENSP00000332103	ENSP00000354972	LSM domain containing 1; Component of the N-terminal acetyltransferase C (NatC) complex which may catalyze acetylation of N-terminal methionine residues	N(alpha)-acetyltransferase 35, NatC auxiliary subunit; Regulates proliferation of smooth muscle cells (By similarity). Component of the N-terminal acetyltransferase C (NatC) complex which may catalyze acetylation of N-terminal methionine residues	0.969
LSMD1	UBC	ENSP00000332103	ENSP00000344818	LSM domain containing 1; Component of the N-terminal acetyltransferase C (NatC) complex which may catalyze acetylation of N-terminal methionine residues	ubiquitin C	0.721
NAA10	HIF1A	ENSP00000417763	ENSP00000338018	N(alpha)-acetyltransferase 10, NatA catalytic subunit; In complex with NAA15, displays alpha (N-terminal) acetyltransferase activity. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to [...]	0.576
NAA10	HYPK	ENSP00000417763	ENSP00000384474	N(alpha)-acetyltransferase 10, NatA catalytic subunit; In complex with NAA15, displays alpha (N-terminal) acetyltransferase activity. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration	huntingtin interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10- NAA15 complex-mediated N-terminal acetylation	0.765
NAA10	LSMD1	ENSP00000417763	ENSP00000332103	N(alpha)-acetyltransferase 10, NatA catalytic subunit; In complex with NAA15, displays alpha (N-terminal) acetyltransferase activity. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration	LSM domain containing 1; Component of the N-terminal acetyltransferase C (NatC) complex which may catalyze acetylation of N-terminal methionine residues	0.720
NAA10	NAA11	ENSP00000417763	ENSP00000286794	N(alpha)-acetyltransferase 10, NatA catalytic subunit; In complex with NAA15, displays alpha (N-terminal) acetyltransferase activity. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration	N(alpha)-acetyltransferase 11, NatA catalytic subunit; In complex with NAA15, displays alpha (N-terminal) acetyltransferase activity	0.723
NAA10	NAA15	ENSP00000417763	ENSP00000296543	N(alpha)-acetyltransferase 10, NatA catalytic subunit; In complex with NAA15, displays alpha (N-terminal) acetyltransferase activity. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration	N(alpha)-acetyltransferase 15, NatA auxiliary subunit; The NAA10-NAA15 complex displays alpha (N-terminal) acetyltransferase activity that may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter	0.989

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