PARP6 protein (Homo sapiens) - STRING network view

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PARP6

poly (ADP-ribose) polymerase family, member 6 (630 aa)

Predicted Functional Partners:

PARP3

0.717

PARP10

0.679

PARP15

0.649

PARP4

0.591

PARP9

0.577

TNKS2

0.574

PARP14

0.558

TNKS

0.553

PARP2

0.542

UBA5

0.538

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PARP10	PARP2	ENSP00000325618	ENSP00000250416	poly (ADP-ribose) polymerase family, member 10; May play a role in cell proliferation. May be required for the maintenance of cell cycle progression	poly (ADP-ribose) polymerase 2; Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks	0.650
PARP10	PARP3	ENSP00000325618	ENSP00000381740	poly (ADP-ribose) polymerase family, member 10; May play a role in cell proliferation. May be required for the maintenance of cell cycle progression	poly (ADP-ribose) polymerase family, member 3; Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May b [...]	0.719
PARP10	PARP4	ENSP00000325618	ENSP00000371419	poly (ADP-ribose) polymerase family, member 10; May play a role in cell proliferation. May be required for the maintenance of cell cycle progression	poly (ADP-ribose) polymerase family, member 4	0.659
PARP10	PARP6	ENSP00000325618	ENSP00000287196	poly (ADP-ribose) polymerase family, member 10; May play a role in cell proliferation. May be required for the maintenance of cell cycle progression	poly (ADP-ribose) polymerase family, member 6	0.679
PARP10	TNKS	ENSP00000325618	ENSP00000311579	poly (ADP-ribose) polymerase family, member 10; May play a role in cell proliferation. May be required for the maintenance of cell cycle progression	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase; Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex- poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequ [...]	0.561
PARP10	TNKS2	ENSP00000325618	ENSP00000360689	poly (ADP-ribose) polymerase family, member 10; May play a role in cell proliferation. May be required for the maintenance of cell cycle progression	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2; Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex- poly-ADP- ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subseque [...]	0.569
PARP14	PARP6	ENSP00000418194	ENSP00000287196	poly (ADP-ribose) polymerase family, member 14; Enhances STAT6-dependent transcription (By similarity). Has ADP-ribosyltransferase activity	poly (ADP-ribose) polymerase family, member 6	0.558
PARP14	PARP9	ENSP00000418194	ENSP00000353512	poly (ADP-ribose) polymerase family, member 14; Enhances STAT6-dependent transcription (By similarity). Has ADP-ribosyltransferase activity	poly (ADP-ribose) polymerase family, member 9; In concert with DTX3L plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. Involved in inducing the expression of IFN-gamma-responsive genes	0.767
PARP15	PARP2	ENSP00000417214	ENSP00000250416	poly (ADP-ribose) polymerase family, member 15; Transcriptional repressor. Has ADP-ribosyltransferase activity	poly (ADP-ribose) polymerase 2; Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks	0.470
PARP15	PARP3	ENSP00000417214	ENSP00000381740	poly (ADP-ribose) polymerase family, member 15; Transcriptional repressor. Has ADP-ribosyltransferase activity	poly (ADP-ribose) polymerase family, member 3; Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May b [...]	0.470
PARP15	PARP4	ENSP00000417214	ENSP00000371419	poly (ADP-ribose) polymerase family, member 15; Transcriptional repressor. Has ADP-ribosyltransferase activity	poly (ADP-ribose) polymerase family, member 4	0.416
PARP15	PARP6	ENSP00000417214	ENSP00000287196	poly (ADP-ribose) polymerase family, member 15; Transcriptional repressor. Has ADP-ribosyltransferase activity	poly (ADP-ribose) polymerase family, member 6	0.649
PARP15	PARP9	ENSP00000417214	ENSP00000353512	poly (ADP-ribose) polymerase family, member 15; Transcriptional repressor. Has ADP-ribosyltransferase activity	poly (ADP-ribose) polymerase family, member 9; In concert with DTX3L plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. Involved in inducing the expression of IFN-gamma-responsive genes	0.509
PARP2	PARP10	ENSP00000250416	ENSP00000325618	poly (ADP-ribose) polymerase 2; Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks	poly (ADP-ribose) polymerase family, member 10; May play a role in cell proliferation. May be required for the maintenance of cell cycle progression	0.650
PARP2	PARP15	ENSP00000250416	ENSP00000417214	poly (ADP-ribose) polymerase 2; Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks	poly (ADP-ribose) polymerase family, member 15; Transcriptional repressor. Has ADP-ribosyltransferase activity	0.470
PARP2	PARP6	ENSP00000250416	ENSP00000287196	poly (ADP-ribose) polymerase 2; Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks	poly (ADP-ribose) polymerase family, member 6	0.542
PARP2	PARP9	ENSP00000250416	ENSP00000353512	poly (ADP-ribose) polymerase 2; Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks	poly (ADP-ribose) polymerase family, member 9; In concert with DTX3L plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. Involved in inducing the expression of IFN-gamma-responsive genes	0.511
PARP2	TNKS	ENSP00000250416	ENSP00000311579	poly (ADP-ribose) polymerase 2; Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase; Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex- poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequ [...]	0.667
PARP2	TNKS2	ENSP00000250416	ENSP00000360689	poly (ADP-ribose) polymerase 2; Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2; Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex- poly-ADP- ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subseque [...]	0.698
PARP3	PARP10	ENSP00000381740	ENSP00000325618	poly (ADP-ribose) polymerase family, member 3; Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May b [...]	poly (ADP-ribose) polymerase family, member 10; May play a role in cell proliferation. May be required for the maintenance of cell cycle progression	0.719

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