node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CMPK2 | DTYMK | ENSP00000256722 | ENSP00000304802 | cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial; May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs | deoxythymidylate kinase (thymidylate kinase); Catalyzes the conversion of dTMP to dTDP | 0.861 |
CMPK2 | RAD17 | ENSP00000256722 | ENSP00000370151 | cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial; May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs | RAD17 homolog (S. pombe) | 0.659 |
CMPK2 | TATDN2 | ENSP00000256722 | ENSP00000287652 | cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial; May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs | TatD DNase domain containing 2; Putative deoxyribonuclease (By similarity) | 0.575 |
CMPK2 | TATDN3 | ENSP00000256722 | ENSP00000431376 | cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial; May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs | TatD DNase domain containing 3 | 0.575 |
CMPK2 | TOP2A | ENSP00000256722 | ENSP00000411532 | cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial; May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs | topoisomerase (DNA) II alpha 170kDa | 0.415 |
CMPK2 | TOP2B | ENSP00000256722 | ENSP00000396704 | cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial; May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs | topoisomerase (DNA) II beta 180kDa; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D- coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene | 0.402 |
CMPK2 | YARS | ENSP00000256722 | ENSP00000362576 | cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial; May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction- tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) | 0.620 |
DIMT1 | TATDN2 | ENSP00000199320 | ENSP00000287652 | DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae); Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3’-end of 18S rRNA in the 40S particle (By similarity) | TatD DNase domain containing 2; Putative deoxyribonuclease (By similarity) | 0.497 |
DIMT1 | TATDN3 | ENSP00000199320 | ENSP00000431376 | DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae); Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3’-end of 18S rRNA in the 40S particle (By similarity) | TatD DNase domain containing 3 | 0.497 |
DIMT1 | TOP2A | ENSP00000199320 | ENSP00000411532 | DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae); Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3’-end of 18S rRNA in the 40S particle (By similarity) | topoisomerase (DNA) II alpha 170kDa | 0.590 |
DIMT1 | TOP2B | ENSP00000199320 | ENSP00000396704 | DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae); Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3’-end of 18S rRNA in the 40S particle (By similarity) | topoisomerase (DNA) II beta 180kDa; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D- coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene | 0.590 |
DIMT1 | YARS | ENSP00000199320 | ENSP00000362576 | DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae); Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3’-end of 18S rRNA in the 40S particle (By similarity) | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction- tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) | 0.680 |
DTYMK | CMPK2 | ENSP00000304802 | ENSP00000256722 | deoxythymidylate kinase (thymidylate kinase); Catalyzes the conversion of dTMP to dTDP | cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial; May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs | 0.861 |
DTYMK | RAD17 | ENSP00000304802 | ENSP00000370151 | deoxythymidylate kinase (thymidylate kinase); Catalyzes the conversion of dTMP to dTDP | RAD17 homolog (S. pombe) | 0.705 |
DTYMK | TATDN2 | ENSP00000304802 | ENSP00000287652 | deoxythymidylate kinase (thymidylate kinase); Catalyzes the conversion of dTMP to dTDP | TatD DNase domain containing 2; Putative deoxyribonuclease (By similarity) | 0.575 |
DTYMK | TATDN3 | ENSP00000304802 | ENSP00000431376 | deoxythymidylate kinase (thymidylate kinase); Catalyzes the conversion of dTMP to dTDP | TatD DNase domain containing 3 | 0.575 |
DTYMK | TOP2A | ENSP00000304802 | ENSP00000411532 | deoxythymidylate kinase (thymidylate kinase); Catalyzes the conversion of dTMP to dTDP | topoisomerase (DNA) II alpha 170kDa | 0.489 |
DTYMK | TOP2B | ENSP00000304802 | ENSP00000396704 | deoxythymidylate kinase (thymidylate kinase); Catalyzes the conversion of dTMP to dTDP | topoisomerase (DNA) II beta 180kDa; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D- coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene | 0.497 |
DTYMK | YARS | ENSP00000304802 | ENSP00000362576 | deoxythymidylate kinase (thymidylate kinase); Catalyzes the conversion of dTMP to dTDP | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction- tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) | 0.620 |
RAD17 | CMPK2 | ENSP00000370151 | ENSP00000256722 | RAD17 homolog (S. pombe) | cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial; May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs | 0.659 |