SLC6A1 protein (Homo sapiens) - STRING network view

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SLC6A1

solute carrier family 6 (neurotransmitter transporter, GABA), member 1; Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals (599 aa)

Predicted Functional Partners:

SEC24D

0.872

MPP5

0.832

GABRD

0.827

ARFGAP1

0.822

ARFGAP3

0.820

GAD1

0.804

SMAD4

0.800

SLC1A1

0.761

GAD2

0.745

GABRA5

0.743

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARFGAP1	ARFGAP3	ENSP00000314615	ENSP00000263245	ADP-ribosylation factor GTPase activating protein 1	ADP-ribosylation factor GTPase activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes	0.885
ARFGAP1	SLC6A1	ENSP00000314615	ENSP00000287766	ADP-ribosylation factor GTPase activating protein 1	solute carrier family 6 (neurotransmitter transporter, GABA), member 1; Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals	0.822
ARFGAP3	ARFGAP1	ENSP00000263245	ENSP00000314615	ADP-ribosylation factor GTPase activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes	ADP-ribosylation factor GTPase activating protein 1	0.885
ARFGAP3	SLC6A1	ENSP00000263245	ENSP00000287766	ADP-ribosylation factor GTPase activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes	solute carrier family 6 (neurotransmitter transporter, GABA), member 1; Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals	0.820
GABRA5	GABRD	ENSP00000335592	ENSP00000367848	gamma-aminobutyric acid (GABA) A receptor, alpha 5; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	gamma-aminobutyric acid (GABA) A receptor, delta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	0.597
GABRA5	SLC6A1	ENSP00000335592	ENSP00000287766	gamma-aminobutyric acid (GABA) A receptor, alpha 5; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	solute carrier family 6 (neurotransmitter transporter, GABA), member 1; Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals	0.743
GABRD	GABRA5	ENSP00000367848	ENSP00000335592	gamma-aminobutyric acid (GABA) A receptor, delta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	gamma-aminobutyric acid (GABA) A receptor, alpha 5; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	0.597
GABRD	GAD1	ENSP00000367848	ENSP00000350928	gamma-aminobutyric acid (GABA) A receptor, delta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA	0.539
GABRD	GAD2	ENSP00000367848	ENSP00000259271	gamma-aminobutyric acid (GABA) A receptor, delta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA	0.462
GABRD	SLC6A1	ENSP00000367848	ENSP00000287766	gamma-aminobutyric acid (GABA) A receptor, delta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	solute carrier family 6 (neurotransmitter transporter, GABA), member 1; Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals	0.827
GAD1	GABRD	ENSP00000350928	ENSP00000367848	glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA	gamma-aminobutyric acid (GABA) A receptor, delta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	0.539
GAD1	GAD2	ENSP00000350928	ENSP00000259271	glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA	0.919
GAD1	SLC6A1	ENSP00000350928	ENSP00000287766	glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA	solute carrier family 6 (neurotransmitter transporter, GABA), member 1; Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals	0.804
GAD2	GABRD	ENSP00000259271	ENSP00000367848	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA	gamma-aminobutyric acid (GABA) A receptor, delta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel	0.462
GAD2	GAD1	ENSP00000259271	ENSP00000350928	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA	glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA	0.919
GAD2	SLC6A1	ENSP00000259271	ENSP00000287766	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA	solute carrier family 6 (neurotransmitter transporter, GABA), member 1; Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals	0.745
MPP5	SEC24D	ENSP00000261681	ENSP00000280551	membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5); May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity)	SEC24 family, member D (S. cerevisiae); Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex	0.496
MPP5	SLC6A1	ENSP00000261681	ENSP00000287766	membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5); May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity)	solute carrier family 6 (neurotransmitter transporter, GABA), member 1; Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals	0.832
SEC24D	MPP5	ENSP00000280551	ENSP00000261681	SEC24 family, member D (S. cerevisiae); Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex	membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5); May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity)	0.496
SEC24D	SLC6A1	ENSP00000280551	ENSP00000287766	SEC24 family, member D (S. cerevisiae); Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex	solute carrier family 6 (neurotransmitter transporter, GABA), member 1; Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals	0.872

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