node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARID4A | ARID4B | ENSP00000347602 | ENSP00000264183 | AT rich interactive domain 4A (RBP1-like); Interacts with the viral protein-binding domain of the retinoblastoma protein | AT rich interactive domain 4B (RBP1-like) | 0.663 |
ARID4A | GATAD1 | ENSP00000347602 | ENSP00000287957 | AT rich interactive domain 4A (RBP1-like); Interacts with the viral protein-binding domain of the retinoblastoma protein | GATA zinc finger domain containing 1; Component of some chromatin complex recruited to chromatin sites methylated ’Lys-4’ of histone H3 (H3K4me) | 0.482 |
ARID4A | HDAC1 | ENSP00000347602 | ENSP00000362649 | AT rich interactive domain 4A (RBP1-like); Interacts with the viral protein-binding domain of the retinoblastoma protein | histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST- mediated transcription in resting neurons. Upon calcium s [...] | 0.993 |
ARID4A | HDAC2 | ENSP00000347602 | ENSP00000430432 | AT rich interactive domain 4A (RBP1-like); Interacts with the viral protein-binding domain of the retinoblastoma protein | histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed o [...] | 0.977 |
ARID4A | HDAC3 | ENSP00000347602 | ENSP00000302967 | AT rich interactive domain 4A (RBP1-like); Interacts with the viral protein-binding domain of the retinoblastoma protein | histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required [...] | 0.972 |
ARID4A | HDAC8 | ENSP00000347602 | ENSP00000362674 | AT rich interactive domain 4A (RBP1-like); Interacts with the viral protein-binding domain of the retinoblastoma protein | histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility | 0.921 |
ARID4A | PHF12 | ENSP00000347602 | ENSP00000329933 | AT rich interactive domain 4A (RBP1-like); Interacts with the viral protein-binding domain of the retinoblastoma protein | PHD finger protein 12; Acts as a transcriptional repressor. Involved in recruitment of functional SIN3A complexes to DNA. Represses transcription at least in part through the activity of an associated histone deacetylase (HDAC). May also repress transcription in a SIN3A-independent manner through recruitment of functional AES complexes to DNA | 0.852 |
ARID4B | ARID4A | ENSP00000264183 | ENSP00000347602 | AT rich interactive domain 4B (RBP1-like) | AT rich interactive domain 4A (RBP1-like); Interacts with the viral protein-binding domain of the retinoblastoma protein | 0.663 |
ARID4B | GATAD1 | ENSP00000264183 | ENSP00000287957 | AT rich interactive domain 4B (RBP1-like) | GATA zinc finger domain containing 1; Component of some chromatin complex recruited to chromatin sites methylated ’Lys-4’ of histone H3 (H3K4me) | 0.482 |
ARID4B | HDAC1 | ENSP00000264183 | ENSP00000362649 | AT rich interactive domain 4B (RBP1-like) | histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST- mediated transcription in resting neurons. Upon calcium s [...] | 0.999 |
ARID4B | HDAC2 | ENSP00000264183 | ENSP00000430432 | AT rich interactive domain 4B (RBP1-like) | histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed o [...] | 0.999 |
ARID4B | HDAC3 | ENSP00000264183 | ENSP00000302967 | AT rich interactive domain 4B (RBP1-like) | histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required [...] | 0.937 |
ARID4B | HDAC8 | ENSP00000264183 | ENSP00000362674 | AT rich interactive domain 4B (RBP1-like) | histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility | 0.919 |
ARID4B | PHF12 | ENSP00000264183 | ENSP00000329933 | AT rich interactive domain 4B (RBP1-like) | PHD finger protein 12; Acts as a transcriptional repressor. Involved in recruitment of functional SIN3A complexes to DNA. Represses transcription at least in part through the activity of an associated histone deacetylase (HDAC). May also repress transcription in a SIN3A-independent manner through recruitment of functional AES complexes to DNA | 0.858 |
ATAD5 | GATAD1 | ENSP00000313171 | ENSP00000287957 | ATPase family, AAA domain containing 5; Involved in DNA damage response. Involved in a RAD9A- related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. Modulates the RAD9A interaction with BCL2 and thereby induces DNA damages- induced apoptosis | GATA zinc finger domain containing 1; Component of some chromatin complex recruited to chromatin sites methylated ’Lys-4’ of histone H3 (H3K4me) | 0.470 |
GATAD1 | ARID4A | ENSP00000287957 | ENSP00000347602 | GATA zinc finger domain containing 1; Component of some chromatin complex recruited to chromatin sites methylated ’Lys-4’ of histone H3 (H3K4me) | AT rich interactive domain 4A (RBP1-like); Interacts with the viral protein-binding domain of the retinoblastoma protein | 0.482 |
GATAD1 | ARID4B | ENSP00000287957 | ENSP00000264183 | GATA zinc finger domain containing 1; Component of some chromatin complex recruited to chromatin sites methylated ’Lys-4’ of histone H3 (H3K4me) | AT rich interactive domain 4B (RBP1-like) | 0.482 |
GATAD1 | ATAD5 | ENSP00000287957 | ENSP00000313171 | GATA zinc finger domain containing 1; Component of some chromatin complex recruited to chromatin sites methylated ’Lys-4’ of histone H3 (H3K4me) | ATPase family, AAA domain containing 5; Involved in DNA damage response. Involved in a RAD9A- related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. Modulates the RAD9A interaction with BCL2 and thereby induces DNA damages- induced apoptosis | 0.470 |
GATAD1 | HDAC1 | ENSP00000287957 | ENSP00000362649 | GATA zinc finger domain containing 1; Component of some chromatin complex recruited to chromatin sites methylated ’Lys-4’ of histone H3 (H3K4me) | histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST- mediated transcription in resting neurons. Upon calcium s [...] | 0.751 |
GATAD1 | HDAC2 | ENSP00000287957 | ENSP00000430432 | GATA zinc finger domain containing 1; Component of some chromatin complex recruited to chromatin sites methylated ’Lys-4’ of histone H3 (H3K4me) | histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed o [...] | 0.626 |