DGKI protein (Homo sapiens) - STRING network view

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DGKI

diacylglycerol kinase, iota (1065 aa)

Predicted Functional Partners:

PLCB1

0.955

PLCB4

0.955

PLCB3

0.955

PLCB2

0.955

PLCD1

0.952

PLCD4

0.952

PLCD3

0.952

PLCE1

0.952

AGPAT4

0.924

PLCZ1

0.921

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGPAT4	DGKI	ENSP00000314036	ENSP00000288490	1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta); Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity)	diacylglycerol kinase, iota	0.924
DGKI	AGPAT4	ENSP00000288490	ENSP00000314036	diacylglycerol kinase, iota	1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta); Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity)	0.924
DGKI	PLCB1	ENSP00000288490	ENSP00000338185	diacylglycerol kinase, iota	phospholipase C, beta 1 (phosphoinositide-specific)	0.955
DGKI	PLCB2	ENSP00000288490	ENSP00000260402	diacylglycerol kinase, iota	phospholipase C, beta 2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes	0.955
DGKI	PLCB3	ENSP00000288490	ENSP00000279230	diacylglycerol kinase, iota	phospholipase C, beta 3 (phosphatidylinositol-specific); The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes	0.955
DGKI	PLCB4	ENSP00000288490	ENSP00000334105	diacylglycerol kinase, iota	phospholipase C, beta 4	0.955
DGKI	PLCD1	ENSP00000288490	ENSP00000430344	diacylglycerol kinase, iota	phospholipase C, delta 1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development	0.952
DGKI	PLCD3	ENSP00000288490	ENSP00000313731	diacylglycerol kinase, iota	phospholipase C, delta 3; Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow	0.952
DGKI	PLCD4	ENSP00000288490	ENSP00000388631	diacylglycerol kinase, iota	phospholipase C, delta 4; Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida- induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overex [...]	0.952
DGKI	PLCE1	ENSP00000288490	ENSP00000260766	diacylglycerol kinase, iota	phospholipase C, epsilon 1	0.952
DGKI	PLCZ1	ENSP00000288490	ENSP00000266505	diacylglycerol kinase, iota	phospholipase C, zeta 1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)- dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg- activating soluble sperm factor that is transferred from the sperm into the egg [...]	0.921
PLCB1	DGKI	ENSP00000338185	ENSP00000288490	phospholipase C, beta 1 (phosphoinositide-specific)	diacylglycerol kinase, iota	0.955
PLCB1	PLCB2	ENSP00000338185	ENSP00000260402	phospholipase C, beta 1 (phosphoinositide-specific)	phospholipase C, beta 2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes	0.904
PLCB1	PLCB3	ENSP00000338185	ENSP00000279230	phospholipase C, beta 1 (phosphoinositide-specific)	phospholipase C, beta 3 (phosphatidylinositol-specific); The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes	0.902
PLCB1	PLCB4	ENSP00000338185	ENSP00000334105	phospholipase C, beta 1 (phosphoinositide-specific)	phospholipase C, beta 4	0.905
PLCB1	PLCD1	ENSP00000338185	ENSP00000430344	phospholipase C, beta 1 (phosphoinositide-specific)	phospholipase C, delta 1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development	0.914
PLCB1	PLCD3	ENSP00000338185	ENSP00000313731	phospholipase C, beta 1 (phosphoinositide-specific)	phospholipase C, delta 3; Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow	0.913
PLCB1	PLCD4	ENSP00000338185	ENSP00000388631	phospholipase C, beta 1 (phosphoinositide-specific)	phospholipase C, delta 4; Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida- induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overex [...]	0.910
PLCB1	PLCE1	ENSP00000338185	ENSP00000260766	phospholipase C, beta 1 (phosphoinositide-specific)	phospholipase C, epsilon 1	0.911
PLCB1	PLCZ1	ENSP00000338185	ENSP00000266505	phospholipase C, beta 1 (phosphoinositide-specific)	phospholipase C, zeta 1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)- dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg- activating soluble sperm factor that is transferred from the sperm into the egg [...]	0.904

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