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SREBF2 SREBF2 SREBF1 SREBF1 ACACA ACACA ACLY ACLY ACACB ACACB ACADS ACADS ALDH18A1 ALDH18A1 ACSM3 ACSM3 EHHADH EHHADH KAT6B KAT6B CBFA2T2 CBFA2T2
"ACSM3" - acyl-CoA synthetase medium-chain family member 3 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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second shell of interactors
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Predicted Interactions
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fusion edge
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protein homology
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Score
ACSM3acyl-CoA synthetase medium-chain family member 3; Has medium-chain fatty acid-CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) (By similarity) (586 aa)    
Predicted Functional Partners:
ACADS
acyl-CoA dehydrogenase, C-2 to C-3 short chain (412 aa)
  score_image   score_image   score_image score_image   0.931
ACACB
acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase (2458 aa)
score_image     score_image score_image   score_image   0.923
ACACA
acetyl-CoA carboxylase alpha (2383 aa)
score_image     score_image score_image   score_image   0.918
ACLY
ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine (1101 aa)
      score_image score_image   score_image   0.885
KAT6B
K(lysine) acetyltransferase 6B; Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (2073 aa)
        score_image   score_image   0.739
CBFA2T2
core-binding factor, runt domain, alpha subunit 2; translocated to, 2 (604 aa)
            score_image   0.703
SREBF2
sterol regulatory element binding transcription factor 2; Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5’-ATCACCCCAC-3’) found in the flanking region of the LDRL and HMG-CoA synthase genes (1141 aa)
            score_image   0.626
SREBF1
sterol regulatory element binding transcription factor 1; Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5’-ATCACCCCAC-3’). Has dual sequence specificity binding to both an E-box motif (5’-ATCACGTGA-3’) and to SRE-1 (5’-ATCACCCCAC-3’) (1177 aa)
            score_image   0.624
ALDH18A1
aldehyde dehydrogenase 18 family, member A1 (795 aa)
score_image           score_image   0.614
EHHADH
enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase (723 aa)
      score_image     score_image   0.592
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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