| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABCB11 | NR1I2 | ENSP00000263817 | ENSP00000336528 | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | nuclear receptor subfamily 1, group I, member 2 | 0.957 |
| ABCB11 | SLC10A1 | ENSP00000263817 | ENSP00000216540 | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | solute carrier family 10 (sodium/bile acid cotransporter family), member 1; The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium | 0.917 |
| ABCB11 | SLC22A7 | ENSP00000263817 | ENSP00000361666 | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | solute carrier family 22 (organic anion transporter), member 7; Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha- ketoglutarate | 0.609 |
| ABCB11 | SLC22A8 | ENSP00000263817 | ENSP00000337335 | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | solute carrier family 22 (organic anion transporter), member 8; Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone- 3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA) | 0.543 |
| ABCB11 | SLCO2B1 | ENSP00000263817 | ENSP00000289575 | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | solute carrier organic anion transporter family, member 2B1; Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost (By similarity) | 0.623 |
| ABCC2 | ABCG2 | ENSP00000359478 | ENSP00000237612 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2; Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter | ATP-binding cassette, sub-family G (WHITE), member 2 | 0.901 |
| ABCC2 | NR1I2 | ENSP00000359478 | ENSP00000336528 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2; Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter | nuclear receptor subfamily 1, group I, member 2 | 0.947 |
| ABCC2 | SLC10A1 | ENSP00000359478 | ENSP00000216540 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2; Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter | solute carrier family 10 (sodium/bile acid cotransporter family), member 1; The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium | 0.778 |
| ABCC2 | SLC15A1 | ENSP00000359478 | ENSP00000365686 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2; Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter | solute carrier family 15 (oligopeptide transporter), member 1; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products | 0.505 |
| ABCC2 | SLC22A7 | ENSP00000359478 | ENSP00000361666 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2; Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter | solute carrier family 22 (organic anion transporter), member 7; Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha- ketoglutarate | 0.533 |
| ABCC2 | SLC22A8 | ENSP00000359478 | ENSP00000337335 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2; Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter | solute carrier family 22 (organic anion transporter), member 8; Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone- 3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA) | 0.749 |
| ABCC2 | SLCO2B1 | ENSP00000359478 | ENSP00000289575 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2; Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter | solute carrier organic anion transporter family, member 2B1; Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost (By similarity) | 0.670 |
| ABCC3 | NR1I2 | ENSP00000285238 | ENSP00000336528 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | nuclear receptor subfamily 1, group I, member 2 | 0.633 |
| ABCC3 | SLC10A1 | ENSP00000285238 | ENSP00000216540 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | solute carrier family 10 (sodium/bile acid cotransporter family), member 1; The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium | 0.975 |
| ABCC3 | SLC15A1 | ENSP00000285238 | ENSP00000365686 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | solute carrier family 15 (oligopeptide transporter), member 1; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products | 0.524 |
| ABCC3 | SLC22A7 | ENSP00000285238 | ENSP00000361666 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | solute carrier family 22 (organic anion transporter), member 7; Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha- ketoglutarate | 0.613 |
| ABCC3 | SLC22A8 | ENSP00000285238 | ENSP00000337335 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | solute carrier family 22 (organic anion transporter), member 8; Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone- 3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA) | 0.613 |
| ABCC3 | SLCO2B1 | ENSP00000285238 | ENSP00000289575 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | solute carrier organic anion transporter family, member 2B1; Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost (By similarity) | 0.611 |
| ABCC4 | NR1I2 | ENSP00000366084 | ENSP00000336528 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4; May be an organic anion pump relevant to cellular detoxification | nuclear receptor subfamily 1, group I, member 2 | 0.537 |
| ABCC4 | SLC10A1 | ENSP00000366084 | ENSP00000216540 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4; May be an organic anion pump relevant to cellular detoxification | solute carrier family 10 (sodium/bile acid cotransporter family), member 1; The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium | 0.681 |
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