| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AGL | EPM2A | ENSP00000294724 | ENSP00000356489 | amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase | epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) | 0.501 |
| AGL | NBL1 | ENSP00000294724 | ENSP00000289749 | amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase | neuroblastoma, suppression of tumorigenicity 1; Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process | 0.482 |
| AGL | NHLRC1 | ENSP00000294724 | ENSP00000345464 | amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase | NHL repeat containing 1; E3 ubiquitin-protein ligase which in complex with EPM2A/laforin and HSP70 suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates PPP1R3C/PTG in a laforin-dependent manner, and targets it for proteasome-dependent degradation and this degradation decreases glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation | 0.886 |
| BAG6 | NBL1 | ENSP00000365131 | ENSP00000289749 | BCL2-associated athanogene 6 | neuroblastoma, suppression of tumorigenicity 1; Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process | 0.576 |
| CER1 | NBL1 | ENSP00000370297 | ENSP00000289749 | cerberus 1, cysteine knot superfamily, homolog (Xenopus laevis); Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak (By similarity) | neuroblastoma, suppression of tumorigenicity 1; Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process | 0.471 |
| COG8 | NBL1 | ENSP00000305459 | ENSP00000289749 | component of oligomeric golgi complex 8; Required for normal Golgi function (By similarity) | neuroblastoma, suppression of tumorigenicity 1; Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process | 0.470 |
| EPB41L4A | NBL1 | ENSP00000261486 | ENSP00000289749 | erythrocyte membrane protein band 4.1 like 4A | neuroblastoma, suppression of tumorigenicity 1; Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process | 0.546 |
| EPM2A | AGL | ENSP00000356489 | ENSP00000294724 | epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) | amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase | 0.501 |
| EPM2A | NBL1 | ENSP00000356489 | ENSP00000289749 | epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) | neuroblastoma, suppression of tumorigenicity 1; Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process | 0.606 |
| EPM2A | NHLRC1 | ENSP00000356489 | ENSP00000345464 | epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) | NHL repeat containing 1; E3 ubiquitin-protein ligase which in complex with EPM2A/laforin and HSP70 suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates PPP1R3C/PTG in a laforin-dependent manner, and targets it for proteasome-dependent degradation and this degradation decreases glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation | 0.999 |
| ID3 | NBL1 | ENSP00000363689 | ENSP00000289749 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein; ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. May inhibit other transcription factors | neuroblastoma, suppression of tumorigenicity 1; Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process | 0.606 |
| NBL1 | AGL | ENSP00000289749 | ENSP00000294724 | neuroblastoma, suppression of tumorigenicity 1; Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process | amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase | 0.482 |
| NBL1 | BAG6 | ENSP00000289749 | ENSP00000365131 | neuroblastoma, suppression of tumorigenicity 1; Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process | BCL2-associated athanogene 6 | 0.576 |
| NBL1 | CER1 | ENSP00000289749 | ENSP00000370297 | neuroblastoma, suppression of tumorigenicity 1; Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process | cerberus 1, cysteine knot superfamily, homolog (Xenopus laevis); Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak (By similarity) | 0.471 |
| NBL1 | COG8 | ENSP00000289749 | ENSP00000305459 | neuroblastoma, suppression of tumorigenicity 1; Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process | component of oligomeric golgi complex 8; Required for normal Golgi function (By similarity) | 0.470 |
| NBL1 | EPB41L4A | ENSP00000289749 | ENSP00000261486 | neuroblastoma, suppression of tumorigenicity 1; Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process | erythrocyte membrane protein band 4.1 like 4A | 0.546 |
| NBL1 | EPM2A | ENSP00000289749 | ENSP00000356489 | neuroblastoma, suppression of tumorigenicity 1; Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process | epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) | 0.606 |
| NBL1 | ID3 | ENSP00000289749 | ENSP00000363689 | neuroblastoma, suppression of tumorigenicity 1; Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein; ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. May inhibit other transcription factors | 0.606 |
| NBL1 | NHLRC1 | ENSP00000289749 | ENSP00000345464 | neuroblastoma, suppression of tumorigenicity 1; Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process | NHL repeat containing 1; E3 ubiquitin-protein ligase which in complex with EPM2A/laforin and HSP70 suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates PPP1R3C/PTG in a laforin-dependent manner, and targets it for proteasome-dependent degradation and this degradation decreases glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation | 0.750 |
| NBL1 | SLC1A1 | ENSP00000289749 | ENSP00000262352 | neuroblastoma, suppression of tumorigenicity 1; Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1; Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity) | 0.496 |
Share
