node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADCY5 | CRH | ENSP00000419361 | ENSP00000276571 | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland | 0.906 |
ADCY5 | GNAS | ENSP00000419361 | ENSP00000360141 | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | GNAS complex locus; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase- it activates the cyclase in response to beta-adrenergic stimuli. XLas isoforms interact with the same set of receptors as Gnas isoforms (By similarity) | 0.973 |
ADCY5 | HTR4 | ENSP00000419361 | ENSP00000353915 | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled | 0.907 |
ADCY5 | HTR6 | ENSP00000419361 | ENSP00000289753 | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs | 0.915 |
ADCY5 | HTR7 | ENSP00000419361 | ENSP00000337949 | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase | 0.924 |
ADCY5 | NPS | ENSP00000419361 | ENSP00000381105 | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity) | 0.905 |
ADCY5 | POMC | ENSP00000419361 | ENSP00000264708 | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol | 0.913 |
ADCY5 | VIP | ENSP00000419361 | ENSP00000356213 | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | vasoactive intestinal peptide; VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder | 0.905 |
ADCY5 | VIPR1 | ENSP00000419361 | ENSP00000327246 | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | vasoactive intestinal peptide receptor 1; This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The affinity is VIP = PACAP-27 > PACAP-38 | 0.904 |
CRH | ADCY5 | ENSP00000276571 | ENSP00000419361 | corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | 0.906 |
CRH | GNAS | ENSP00000276571 | ENSP00000360141 | corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland | GNAS complex locus; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase- it activates the cyclase in response to beta-adrenergic stimuli. XLas isoforms interact with the same set of receptors as Gnas isoforms (By similarity) | 0.918 |
CRH | HTR4 | ENSP00000276571 | ENSP00000353915 | corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland | 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled | 0.938 |
CRH | HTR6 | ENSP00000276571 | ENSP00000289753 | corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland | 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs | 0.929 |
CRH | HTR7 | ENSP00000276571 | ENSP00000337949 | corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland | 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase | 0.961 |
CRH | NPS | ENSP00000276571 | ENSP00000381105 | corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland | neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity) | 0.987 |
CRH | POMC | ENSP00000276571 | ENSP00000264708 | corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland | proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol | 0.998 |
CRH | VIP | ENSP00000276571 | ENSP00000356213 | corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland | vasoactive intestinal peptide; VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder | 0.968 |
CRH | VIPR1 | ENSP00000276571 | ENSP00000327246 | corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland | vasoactive intestinal peptide receptor 1; This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The affinity is VIP = PACAP-27 > PACAP-38 | 0.923 |
FYN | HTR6 | ENSP00000346671 | ENSP00000289753 | FYN oncogene related to SRC, FGR, YES; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motilit [...] | 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs | 0.919 |
GNAS | ADCY5 | ENSP00000360141 | ENSP00000419361 | GNAS complex locus; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase- it activates the cyclase in response to beta-adrenergic stimuli. XLas isoforms interact with the same set of receptors as Gnas isoforms (By similarity) | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | 0.973 |