node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EDDM3A | WFDC8 | ENSP00000315098 | ENSP00000289953 | epididymal protein 3A; Possible function in sperm maturation | WAP four-disulfide core domain 8 | 0.426 |
ELSPBP1 | WFDC8 | ENSP00000340660 | ENSP00000289953 | epididymal sperm binding protein 1; Binds to spermatozoa upon ejaculation and may play a role in sperm capacitation. Has phosphorylcholine-binding activity (By similarity) | WAP four-disulfide core domain 8 | 0.484 |
ERAP2 | SPINT4 | ENSP00000400376 | ENSP00000279058 | endoplasmic reticulum aminopeptidase 2; Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I- binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys | serine peptidase inhibitor, Kunitz type 4 | 0.579 |
ERAP2 | WFDC8 | ENSP00000400376 | ENSP00000289953 | endoplasmic reticulum aminopeptidase 2; Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I- binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys | WAP four-disulfide core domain 8 | 0.567 |
GAPDHS | SPINT4 | ENSP00000222286 | ENSP00000279058 | glyceraldehyde-3-phosphate dehydrogenase, spermatogenic; May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity) | serine peptidase inhibitor, Kunitz type 4 | 0.470 |
GAPDHS | WFDC8 | ENSP00000222286 | ENSP00000289953 | glyceraldehyde-3-phosphate dehydrogenase, spermatogenic; May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity) | WAP four-disulfide core domain 8 | 0.444 |
SEMG2 | SPINT4 | ENSP00000361855 | ENSP00000279058 | semenogelin II; Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa | serine peptidase inhibitor, Kunitz type 4 | 0.625 |
SEMG2 | WFDC8 | ENSP00000361855 | ENSP00000289953 | semenogelin II; Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa | WAP four-disulfide core domain 8 | 0.517 |
SPINT4 | ERAP2 | ENSP00000279058 | ENSP00000400376 | serine peptidase inhibitor, Kunitz type 4 | endoplasmic reticulum aminopeptidase 2; Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I- binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys | 0.579 |
SPINT4 | GAPDHS | ENSP00000279058 | ENSP00000222286 | serine peptidase inhibitor, Kunitz type 4 | glyceraldehyde-3-phosphate dehydrogenase, spermatogenic; May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity) | 0.470 |
SPINT4 | SEMG2 | ENSP00000279058 | ENSP00000361855 | serine peptidase inhibitor, Kunitz type 4 | semenogelin II; Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa | 0.625 |
SPINT4 | UCP3 | ENSP00000279058 | ENSP00000323740 | serine peptidase inhibitor, Kunitz type 4 | uncoupling protein 3 (mitochondrial, proton carrier); UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance | 0.526 |
SPINT4 | WFDC6 | ENSP00000279058 | ENSP00000361755 | serine peptidase inhibitor, Kunitz type 4 | WAP four-disulfide core domain 6 | 0.702 |
SPINT4 | WFDC8 | ENSP00000279058 | ENSP00000289953 | serine peptidase inhibitor, Kunitz type 4 | WAP four-disulfide core domain 8 | 0.890 |
UCP3 | SPINT4 | ENSP00000323740 | ENSP00000279058 | uncoupling protein 3 (mitochondrial, proton carrier); UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance | serine peptidase inhibitor, Kunitz type 4 | 0.526 |
UCP3 | WFDC8 | ENSP00000323740 | ENSP00000289953 | uncoupling protein 3 (mitochondrial, proton carrier); UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance | WAP four-disulfide core domain 8 | 0.491 |
WFDC6 | SPINT4 | ENSP00000361755 | ENSP00000279058 | WAP four-disulfide core domain 6 | serine peptidase inhibitor, Kunitz type 4 | 0.702 |
WFDC6 | WFDC8 | ENSP00000361755 | ENSP00000289953 | WAP four-disulfide core domain 6 | WAP four-disulfide core domain 8 | 0.580 |
WFDC8 | EDDM3A | ENSP00000289953 | ENSP00000315098 | WAP four-disulfide core domain 8 | epididymal protein 3A; Possible function in sperm maturation | 0.426 |
WFDC8 | ELSPBP1 | ENSP00000289953 | ENSP00000340660 | WAP four-disulfide core domain 8 | epididymal sperm binding protein 1; Binds to spermatozoa upon ejaculation and may play a role in sperm capacitation. Has phosphorylcholine-binding activity (By similarity) | 0.484 |