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STRINGSTRING
SEMG2 SEMG2 ERAP2 ERAP2 WFDC6 WFDC6 SPINT4 SPINT4 ELSPBP1 ELSPBP1 WFDC8 WFDC8 GAPDHS GAPDHS UCP3 UCP3 EDDM3A EDDM3A
"WFDC8" - WAP four-disulfide core domain 8 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored protein node
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
WFDC8WAP four-disulfide core domain 8 (241 aa)    
Predicted Functional Partners:
SPINT4
serine peptidase inhibitor, Kunitz type 4 (99 aa)
            score_image   0.890
WFDC6
WAP four-disulfide core domain 6 (86 aa)
            score_image   0.580
ERAP2
endoplasmic reticulum aminopeptidase 2; Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I- binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys (960 aa)
            score_image   0.567
SEMG2
semenogelin II; Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa (582 aa)
            score_image   0.517
UCP3
uncoupling protein 3 (mitochondrial, proton carrier); UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance (312 aa)
            score_image   0.491
ELSPBP1
epididymal sperm binding protein 1; Binds to spermatozoa upon ejaculation and may play a role in sperm capacitation. Has phosphorylcholine-binding activity (By similarity) (223 aa)
            score_image   0.484
GAPDHS
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic; May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity) (408 aa)
            score_image   0.444
EDDM3A
epididymal protein 3A; Possible function in sperm maturation (147 aa)
            score_image   0.426
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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