node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FKBP5 | MAGED2 | ENSP00000338160 | ENSP00000218439 | FK506 binding protein 5; Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP | melanoma antigen family D, 2 | 0.645 |
FKBP5 | OGFR | ENSP00000338160 | ENSP00000290291 | FK506 binding protein 5; Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP | opioid growth factor receptor | 0.538 |
FKBP5 | TRAP1 | ENSP00000338160 | ENSP00000246957 | FK506 binding protein 5; Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP | TNF receptor-associated protein 1; Chaperone that expresses an ATPase activity | 0.779 |
FKBP5 | UBC | ENSP00000338160 | ENSP00000344818 | FK506 binding protein 5; Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP | ubiquitin C | 0.818 |
FKBP5 | USP7 | ENSP00000338160 | ENSP00000343535 | FK506 binding protein 5; Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP | ubiquitin specific peptidase 7 (herpes virus-associated); Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53- dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen pero [...] | 0.538 |
GPX7 | OGFR | ENSP00000354677 | ENSP00000290291 | glutathione peroxidase 7; It protects esophageal epithelia from hydrogen peroxide- induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks | opioid growth factor receptor | 0.489 |
LAGE3 | MAGED2 | ENSP00000349923 | ENSP00000218439 | L antigen family, member 3 | melanoma antigen family D, 2 | 0.644 |
LAGE3 | OGFR | ENSP00000349923 | ENSP00000290291 | L antigen family, member 3 | opioid growth factor receptor | 0.644 |
LAGE3 | UBC | ENSP00000349923 | ENSP00000344818 | L antigen family, member 3 | ubiquitin C | 0.925 |
MAGED2 | FKBP5 | ENSP00000218439 | ENSP00000338160 | melanoma antigen family D, 2 | FK506 binding protein 5; Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP | 0.645 |
MAGED2 | LAGE3 | ENSP00000218439 | ENSP00000349923 | melanoma antigen family D, 2 | L antigen family, member 3 | 0.644 |
MAGED2 | OGFR | ENSP00000218439 | ENSP00000290291 | melanoma antigen family D, 2 | opioid growth factor receptor | 0.538 |
MAGED2 | TRAP1 | ENSP00000218439 | ENSP00000246957 | melanoma antigen family D, 2 | TNF receptor-associated protein 1; Chaperone that expresses an ATPase activity | 0.565 |
MAGED2 | UBC | ENSP00000218439 | ENSP00000344818 | melanoma antigen family D, 2 | ubiquitin C | 0.978 |
MAGED2 | USP7 | ENSP00000218439 | ENSP00000343535 | melanoma antigen family D, 2 | ubiquitin specific peptidase 7 (herpes virus-associated); Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53- dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen pero [...] | 0.574 |
OGFR | FKBP5 | ENSP00000290291 | ENSP00000338160 | opioid growth factor receptor | FK506 binding protein 5; Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP | 0.538 |
OGFR | GPX7 | ENSP00000290291 | ENSP00000354677 | opioid growth factor receptor | glutathione peroxidase 7; It protects esophageal epithelia from hydrogen peroxide- induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks | 0.489 |
OGFR | LAGE3 | ENSP00000290291 | ENSP00000349923 | opioid growth factor receptor | L antigen family, member 3 | 0.644 |
OGFR | MAGED2 | ENSP00000290291 | ENSP00000218439 | opioid growth factor receptor | melanoma antigen family D, 2 | 0.538 |
OGFR | PENK | ENSP00000290291 | ENSP00000324248 | opioid growth factor receptor | proenkephalin; Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum | 0.747 |