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CREB1 CREB1 IL2RG IL2RG ANO1 ANO1 CLIC6 CLIC6 BEST2 BEST2 CLCNKB CLCNKB SLC26A6 SLC26A6 CLCN1 CLCN1 KCNJ13 KCNJ13 CLCNKA CLCNKA CFTR CFTR
"CLIC6" - chloride intracellular channel 6 in Homo sapiens
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protein of unknown 3D structure
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Predicted Interactions
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Score
CLIC6chloride intracellular channel 6; May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity) (686 aa)    
Predicted Functional Partners:
CREB1
cAMP responsive element binding protein 1; Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells (341 aa)
             score_image   0.620
CLCN1
chloride channel, voltage-sensitive 1; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport (988 aa)
           score_image score_image   0.614
CLCNKA
chloride channel, voltage-sensitive Ka; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms (687 aa)
           score_image score_image   0.610
BEST2
bestrophin 2; Forms calcium-sensitive chloride channels. Permeable to bicarbonate (509 aa)
           score_image score_image   0.607
CLCNKB
chloride channel, voltage-sensitive Kb; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms (687 aa)
           score_image score_image   0.602
SLC26A6
solute carrier family 26, member 6; Does not seem to be involved in anion transport (759 aa)
           score_image score_image   0.597
ANO1
anoctamin 1, calcium activated chloride channel; Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development (986 aa)
           score_image score_image   0.595
IL2RG
interleukin 2 receptor, gamma; Common subunit for the receptors for a variety of interleukins (369 aa)
             score_image   0.580
KCNJ13
potassium inwardly-rectifying channel, subfamily J, member 13; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and [...] (360 aa)
             score_image   0.579
CFTR
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1 (1480 aa)
           score_image score_image   0.575
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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