| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CD2AP | PKD2L2 | ENSP00000352264 | ENSP00000290431 | CD2-associated protein; Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. May play a role in receptor clustering and cytoskeletal polarity in the junction between T- cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis | polycystic kidney disease 2-like 2; May function as a subunit of a cation channel and play a role in fertilization | 0.758 |
| CD2AP | SH3KBP1 | ENSP00000352264 | ENSP00000380921 | CD2-associated protein; Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. May play a role in receptor clustering and cytoskeletal polarity in the junction between T- cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis | SH3-domain kinase binding protein 1; Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by intera [...] | 0.834 |
| CSNK2A1 | CSNK2A2 | ENSP00000217244 | ENSP00000262506 | casein kinase 2, alpha 1 polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly che [...] | casein kinase 2, alpha prime polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly [...] | 0.788 |
| CSNK2A1 | PKD2L2 | ENSP00000217244 | ENSP00000290431 | casein kinase 2, alpha 1 polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly che [...] | polycystic kidney disease 2-like 2; May function as a subunit of a cation channel and play a role in fertilization | 0.831 |
| CSNK2A2 | CSNK2A1 | ENSP00000262506 | ENSP00000217244 | casein kinase 2, alpha prime polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly [...] | casein kinase 2, alpha 1 polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly che [...] | 0.788 |
| CSNK2A2 | PKD2L2 | ENSP00000262506 | ENSP00000290431 | casein kinase 2, alpha prime polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly [...] | polycystic kidney disease 2-like 2; May function as a subunit of a cation channel and play a role in fertilization | 0.831 |
| PKD2L2 | CD2AP | ENSP00000290431 | ENSP00000352264 | polycystic kidney disease 2-like 2; May function as a subunit of a cation channel and play a role in fertilization | CD2-associated protein; Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. May play a role in receptor clustering and cytoskeletal polarity in the junction between T- cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis | 0.758 |
| PKD2L2 | CSNK2A1 | ENSP00000290431 | ENSP00000217244 | polycystic kidney disease 2-like 2; May function as a subunit of a cation channel and play a role in fertilization | casein kinase 2, alpha 1 polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly che [...] | 0.831 |
| PKD2L2 | CSNK2A2 | ENSP00000290431 | ENSP00000262506 | polycystic kidney disease 2-like 2; May function as a subunit of a cation channel and play a role in fertilization | casein kinase 2, alpha prime polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly [...] | 0.831 |
| PKD2L2 | SH3D21 | ENSP00000290431 | ENSP00000403476 | polycystic kidney disease 2-like 2; May function as a subunit of a cation channel and play a role in fertilization | SH3 domain containing 21 | 0.612 |
| PKD2L2 | SH3KBP1 | ENSP00000290431 | ENSP00000380921 | polycystic kidney disease 2-like 2; May function as a subunit of a cation channel and play a role in fertilization | SH3-domain kinase binding protein 1; Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by intera [...] | 0.758 |
| PKD2L2 | TRPM1 | ENSP00000290431 | ENSP00000380897 | polycystic kidney disease 2-like 2; May function as a subunit of a cation channel and play a role in fertilization | transient receptor potential cation channel, subfamily M, member 1; Cation channel essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. May play a role in metastasis suppression (By similarity). May act as a spontaneously active, calcium-permeable plasma membrane channel | 0.608 |
| PKD2L2 | TRPM2 | ENSP00000290431 | ENSP00000300482 | polycystic kidney disease 2-like 2; May function as a subunit of a cation channel and play a role in fertilization | transient receptor potential cation channel, subfamily M, member 2; Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has [...] | 0.614 |
| PKD2L2 | TRPM3 | ENSP00000290431 | ENSP00000366314 | polycystic kidney disease 2-like 2; May function as a subunit of a cation channel and play a role in fertilization | transient receptor potential cation channel, subfamily M, member 3 | 0.640 |
| PKD2L2 | TRPM4 | ENSP00000290431 | ENSP00000252826 | polycystic kidney disease 2-like 2; May function as a subunit of a cation channel and play a role in fertilization | transient receptor potential cation channel, subfamily M, member 4; Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulati [...] | 0.644 |
| PKD2L2 | TRPM7 | ENSP00000290431 | ENSP00000320239 | polycystic kidney disease 2-like 2; May function as a subunit of a cation channel and play a role in fertilization | transient receptor potential cation channel, subfamily M, member 7; Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1) | 0.646 |
| SH3D21 | PKD2L2 | ENSP00000403476 | ENSP00000290431 | SH3 domain containing 21 | polycystic kidney disease 2-like 2; May function as a subunit of a cation channel and play a role in fertilization | 0.612 |
| SH3KBP1 | CD2AP | ENSP00000380921 | ENSP00000352264 | SH3-domain kinase binding protein 1; Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by intera [...] | CD2-associated protein; Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. May play a role in receptor clustering and cytoskeletal polarity in the junction between T- cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis | 0.834 |
| SH3KBP1 | PKD2L2 | ENSP00000380921 | ENSP00000290431 | SH3-domain kinase binding protein 1; Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by intera [...] | polycystic kidney disease 2-like 2; May function as a subunit of a cation channel and play a role in fertilization | 0.758 |
| TRPM1 | PKD2L2 | ENSP00000380897 | ENSP00000290431 | transient receptor potential cation channel, subfamily M, member 1; Cation channel essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. May play a role in metastasis suppression (By similarity). May act as a spontaneously active, calcium-permeable plasma membrane channel | polycystic kidney disease 2-like 2; May function as a subunit of a cation channel and play a role in fertilization | 0.608 |
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