Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
GBA3 GBA3 TRIP13 TRIP13 ENSG00000262314 ENSG00000262314 CRX CRX RNASET2 RNASET2 NDRG4 NDRG4 C2orf65 C2orf65 DQX1 DQX1 GPKOW GPKOW EGFL6 EGFL6 FAM196B FAM196B
"C2orf65" - chromosome 2 open reading frame 65 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C2orf65chromosome 2 open reading frame 65; Required for meiosis I progression during spermatogenesis (By similarity) (530 aa)    
Predicted Functional Partners:
CRX
cone-rod homeobox; Binds and transactivates the sequence 5’-TAATC[CA]-3’ which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, e.g. NRL and RX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors (299 aa)
        score_image       0.677
EGFL6
EGF-like-domain, multiple 6; May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity) (554 aa)
            score_image   0.672
FAM196B
family with sequence similarity 196, member B (535 aa)
            score_image   0.644
NDRG4
NDRG family member 4 (391 aa)
            score_image   0.598
GPKOW
G patch domain and KOW motifs (476 aa)
            score_image   0.560
ENSG00000262314
Spermatogenesis-associated protein 22; Uncharacterized protein (347 aa)
            score_image   0.515
DQX1
DEAQ box RNA-dependent ATPase 1 (717 aa)
            score_image   0.506
RNASET2
ribonuclease T2; Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity). Probably plays a role in cellular RNA catabolism (256 aa)
            score_image   0.478
TRIP13
thyroid hormone receptor interactor 13; Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for [...] (432 aa)
        score_image   score_image   0.434
GBA3
Cytosolic beta-glucosidase ; Glycosidase probably involved in the intestinal absorption and metabolism of dietary flavonoid glycosides. Able to hydrolyze a broad variety of glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens. Possesses beta- glycosylceramidase activity and may be involved in a nonlysosomal catabolic pathway of glycosylceramide (469 aa)
            score_image   0.408
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (26%)