node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C12orf5 | FBP1 | ENSP00000179259 | ENSP00000364475 | chromosome 12 open reading frame 5; Fructose-bisphosphatase hydrolyzing fructose-2,6- bisphosphate as well as fructose-1,6-bisphosphate. Inhibits glycolysis by reducing cellular levels of fructose-2,6- bisphosphate. May protect cells against reactive oxygen species and against apoptosis induced by tp53 | fructose-1,6-bisphosphatase 1 | 0.916 |
C12orf5 | FBP2 | ENSP00000179259 | ENSP00000364486 | chromosome 12 open reading frame 5; Fructose-bisphosphatase hydrolyzing fructose-2,6- bisphosphate as well as fructose-1,6-bisphosphate. Inhibits glycolysis by reducing cellular levels of fructose-2,6- bisphosphate. May protect cells against reactive oxygen species and against apoptosis induced by tp53 | fructose-1,6-bisphosphatase 2 | 0.918 |
C12orf5 | GPI | ENSP00000179259 | ENSP00000405573 | chromosome 12 open reading frame 5; Fructose-bisphosphatase hydrolyzing fructose-2,6- bisphosphate as well as fructose-1,6-bisphosphate. Inhibits glycolysis by reducing cellular levels of fructose-2,6- bisphosphate. May protect cells against reactive oxygen species and against apoptosis induced by tp53 | glucose-6-phosphate isomerase; Besides it’s role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons | 0.502 |
C12orf5 | HK2 | ENSP00000179259 | ENSP00000290573 | chromosome 12 open reading frame 5; Fructose-bisphosphatase hydrolyzing fructose-2,6- bisphosphate as well as fructose-1,6-bisphosphate. Inhibits glycolysis by reducing cellular levels of fructose-2,6- bisphosphate. May protect cells against reactive oxygen species and against apoptosis induced by tp53 | hexokinase 2 | 0.995 |
C12orf5 | PFKFB2 | ENSP00000179259 | ENSP00000356047 | chromosome 12 open reading frame 5; Fructose-bisphosphatase hydrolyzing fructose-2,6- bisphosphate as well as fructose-1,6-bisphosphate. Inhibits glycolysis by reducing cellular levels of fructose-2,6- bisphosphate. May protect cells against reactive oxygen species and against apoptosis induced by tp53 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2; Synthesis and degradation of fructose 2,6-bisphosphate | 0.453 |
C12orf5 | PFKFB3 | ENSP00000179259 | ENSP00000369100 | chromosome 12 open reading frame 5; Fructose-bisphosphatase hydrolyzing fructose-2,6- bisphosphate as well as fructose-1,6-bisphosphate. Inhibits glycolysis by reducing cellular levels of fructose-2,6- bisphosphate. May protect cells against reactive oxygen species and against apoptosis induced by tp53 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3; Synthesis and degradation of fructose 2,6-bisphosphate | 0.503 |
C12orf5 | PFKL | ENSP00000179259 | ENSP00000269848 | chromosome 12 open reading frame 5; Fructose-bisphosphatase hydrolyzing fructose-2,6- bisphosphate as well as fructose-1,6-bisphosphate. Inhibits glycolysis by reducing cellular levels of fructose-2,6- bisphosphate. May protect cells against reactive oxygen species and against apoptosis induced by tp53 | phosphofructokinase, liver; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP | 0.927 |
C12orf5 | PFKM | ENSP00000179259 | ENSP00000345771 | chromosome 12 open reading frame 5; Fructose-bisphosphatase hydrolyzing fructose-2,6- bisphosphate as well as fructose-1,6-bisphosphate. Inhibits glycolysis by reducing cellular levels of fructose-2,6- bisphosphate. May protect cells against reactive oxygen species and against apoptosis induced by tp53 | phosphofructokinase, muscle; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP | 0.960 |
C12orf5 | PFKP | ENSP00000179259 | ENSP00000370517 | chromosome 12 open reading frame 5; Fructose-bisphosphatase hydrolyzing fructose-2,6- bisphosphate as well as fructose-1,6-bisphosphate. Inhibits glycolysis by reducing cellular levels of fructose-2,6- bisphosphate. May protect cells against reactive oxygen species and against apoptosis induced by tp53 | phosphofructokinase, platelet; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP | 0.930 |
FBP1 | C12orf5 | ENSP00000364475 | ENSP00000179259 | fructose-1,6-bisphosphatase 1 | chromosome 12 open reading frame 5; Fructose-bisphosphatase hydrolyzing fructose-2,6- bisphosphate as well as fructose-1,6-bisphosphate. Inhibits glycolysis by reducing cellular levels of fructose-2,6- bisphosphate. May protect cells against reactive oxygen species and against apoptosis induced by tp53 | 0.916 |
FBP1 | FBP2 | ENSP00000364475 | ENSP00000364486 | fructose-1,6-bisphosphatase 1 | fructose-1,6-bisphosphatase 2 | 0.821 |
FBP1 | GPI | ENSP00000364475 | ENSP00000405573 | fructose-1,6-bisphosphatase 1 | glucose-6-phosphate isomerase; Besides it’s role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons | 0.955 |
FBP1 | HK2 | ENSP00000364475 | ENSP00000290573 | fructose-1,6-bisphosphatase 1 | hexokinase 2 | 0.960 |
FBP1 | PFKFB2 | ENSP00000364475 | ENSP00000356047 | fructose-1,6-bisphosphatase 1 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2; Synthesis and degradation of fructose 2,6-bisphosphate | 0.951 |
FBP1 | PFKFB3 | ENSP00000364475 | ENSP00000369100 | fructose-1,6-bisphosphatase 1 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3; Synthesis and degradation of fructose 2,6-bisphosphate | 0.947 |
FBP1 | PFKL | ENSP00000364475 | ENSP00000269848 | fructose-1,6-bisphosphatase 1 | phosphofructokinase, liver; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP | 0.831 |
FBP1 | PFKM | ENSP00000364475 | ENSP00000345771 | fructose-1,6-bisphosphatase 1 | phosphofructokinase, muscle; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP | 0.830 |
FBP1 | PFKP | ENSP00000364475 | ENSP00000370517 | fructose-1,6-bisphosphatase 1 | phosphofructokinase, platelet; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP | 0.824 |
FBP1 | PGM1 | ENSP00000364475 | ENSP00000360124 | fructose-1,6-bisphosphatase 1 | phosphoglucomutase 1 | 0.434 |
FBP2 | C12orf5 | ENSP00000364486 | ENSP00000179259 | fructose-1,6-bisphosphatase 2 | chromosome 12 open reading frame 5; Fructose-bisphosphatase hydrolyzing fructose-2,6- bisphosphate as well as fructose-1,6-bisphosphate. Inhibits glycolysis by reducing cellular levels of fructose-2,6- bisphosphate. May protect cells against reactive oxygen species and against apoptosis induced by tp53 | 0.918 |