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STRINGSTRING
PFKFB3 PFKFB3 FBP1 FBP1 PFKP PFKP FBP2 FBP2 HK2 HK2 GPI GPI PFKFB2 PFKFB2 C12orf5 C12orf5 PFKL PFKL PFKM PFKM PGM1 PGM1
"HK2" - hexokinase 2 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
large protein node
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some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Edges represent protein-protein associations
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Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
HK2hexokinase 2 (917 aa)    
Predicted Functional Partners:
C12orf5
chromosome 12 open reading frame 5; Fructose-bisphosphatase hydrolyzing fructose-2,6- bisphosphate as well as fructose-1,6-bisphosphate. Inhibits glycolysis by reducing cellular levels of fructose-2,6- bisphosphate. May protect cells against reactive oxygen species and against apoptosis induced by tp53 (270 aa)
        score_image score_image score_image   0.995
PFKM
phosphofructokinase, muscle; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP (851 aa)
      score_image   score_image score_image   0.990
PFKP
phosphofructokinase, platelet; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP (784 aa)
      score_image   score_image score_image   0.987
PFKL
phosphofructokinase, liver; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP (780 aa)
      score_image   score_image score_image   0.987
GPI
glucose-6-phosphate isomerase; Besides it’s role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons (569 aa)
      score_image   score_image score_image   0.981
PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3; Synthesis and degradation of fructose 2,6-bisphosphate (520 aa)
          score_image score_image   0.972
PGM1
phosphoglucomutase 1 (580 aa)
      score_image   score_image score_image   0.969
FBP2
fructose-1,6-bisphosphatase 2 (339 aa)
          score_image score_image   0.963
FBP1
fructose-1,6-bisphosphatase 1 (338 aa)
          score_image score_image   0.960
PFKFB2
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2; Synthesis and degradation of fructose 2,6-bisphosphate (505 aa)
          score_image score_image   0.960
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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