node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATP6V1A | CSE1L | ENSP00000273398 | ENSP00000262982 | ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells | CSE1 chromosome segregation 1-like (yeast) | 0.915 |
ATP6V1A | UBC | ENSP00000273398 | ENSP00000344818 | ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells | ubiquitin C | 0.978 |
ATP6V1A | UBR1 | ENSP00000273398 | ENSP00000290650 | ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells | ubiquitin protein ligase E3 component n-recognin 1; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth | 0.903 |
ATP6V1A | ZNF593 | ENSP00000273398 | ENSP00000363384 | ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells | zinc finger protein 593; Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity. Could act either by binding to DNA octamer or by interacting with Oct-2. May also be a modulator of other octamer-binding proteins | 0.644 |
C6orf108 | UBC | ENSP00000230431 | ENSP00000344818 | chromosome 6 open reading frame 108; Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5’-monophosphates to yield deoxyribose 5- phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5’- monophosphates containing purine bases are preferred to those containing pyrimidine bases (By similarity) | ubiquitin C | 0.483 |
C6orf108 | UBR1 | ENSP00000230431 | ENSP00000290650 | chromosome 6 open reading frame 108; Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5’-monophosphates to yield deoxyribose 5- phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5’- monophosphates containing purine bases are preferred to those containing pyrimidine bases (By similarity) | ubiquitin protein ligase E3 component n-recognin 1; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth | 0.920 |
C6orf108 | ZNF593 | ENSP00000230431 | ENSP00000363384 | chromosome 6 open reading frame 108; Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5’-monophosphates to yield deoxyribose 5- phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5’- monophosphates containing purine bases are preferred to those containing pyrimidine bases (By similarity) | zinc finger protein 593; Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity. Could act either by binding to DNA octamer or by interacting with Oct-2. May also be a modulator of other octamer-binding proteins | 0.904 |
CSE1L | ATP6V1A | ENSP00000262982 | ENSP00000273398 | CSE1 chromosome segregation 1-like (yeast) | ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells | 0.915 |
CSE1L | UBC | ENSP00000262982 | ENSP00000344818 | CSE1 chromosome segregation 1-like (yeast) | ubiquitin C | 0.983 |
CSE1L | UBE2A | ENSP00000262982 | ENSP00000360613 | CSE1 chromosome segregation 1-like (yeast) | ubiquitin-conjugating enzyme E2A; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at ’Lys-120’ to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes ’Lys-11’, as well as ’Lys-48’-linked polyubiquitination. Require [...] | 0.839 |
CSE1L | UBR1 | ENSP00000262982 | ENSP00000290650 | CSE1 chromosome segregation 1-like (yeast) | ubiquitin protein ligase E3 component n-recognin 1; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth | 0.941 |
CSE1L | UCHL3 | ENSP00000262982 | ENSP00000366819 | CSE1 chromosome segregation 1-like (yeast) | ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase); Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3", and exhibits a preference towards ’Lys-48’-linked Ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGF [...] | 0.673 |
PFAS | UBC | ENSP00000313490 | ENSP00000344818 | phosphoribosylformylglycinamidine synthase | ubiquitin C | 0.982 |
PFAS | UBR1 | ENSP00000313490 | ENSP00000290650 | phosphoribosylformylglycinamidine synthase | ubiquitin protein ligase E3 component n-recognin 1; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth | 0.910 |
PFAS | ZNF593 | ENSP00000313490 | ENSP00000363384 | phosphoribosylformylglycinamidine synthase | zinc finger protein 593; Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity. Could act either by binding to DNA octamer or by interacting with Oct-2. May also be a modulator of other octamer-binding proteins | 0.818 |
UBC | ATP6V1A | ENSP00000344818 | ENSP00000273398 | ubiquitin C | ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells | 0.978 |
UBC | C6orf108 | ENSP00000344818 | ENSP00000230431 | ubiquitin C | chromosome 6 open reading frame 108; Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5’-monophosphates to yield deoxyribose 5- phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5’- monophosphates containing purine bases are preferred to those containing pyrimidine bases (By similarity) | 0.483 |
UBC | CSE1L | ENSP00000344818 | ENSP00000262982 | ubiquitin C | CSE1 chromosome segregation 1-like (yeast) | 0.983 |
UBC | PFAS | ENSP00000344818 | ENSP00000313490 | ubiquitin C | phosphoribosylformylglycinamidine synthase | 0.982 |
UBC | UBE2A | ENSP00000344818 | ENSP00000360613 | ubiquitin C | ubiquitin-conjugating enzyme E2A; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at ’Lys-120’ to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes ’Lys-11’, as well as ’Lys-48’-linked polyubiquitination. Require [...] | 0.997 |