node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COX10 | OMA1 | ENSP00000261643 | ENSP00000360270 | cytochrome c oxidase assembly homolog 10 (yeast); Converts protoheme IX and farnesyl diphosphate to heme O (By similarity) | OMA1 zinc metallopeptidase homolog (S. cerevisiae); Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions | 0.678 |
COX10 | TEPP | ENSP00000261643 | ENSP00000290871 | cytochrome c oxidase assembly homolog 10 (yeast); Converts protoheme IX and farnesyl diphosphate to heme O (By similarity) | testis, prostate and placenta expressed | 0.414 |
F12 | TEPP | ENSP00000253496 | ENSP00000290871 | coagulation factor XII (Hageman factor); Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta- factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa | testis, prostate and placenta expressed | 0.549 |
OMA1 | COX10 | ENSP00000360270 | ENSP00000261643 | OMA1 zinc metallopeptidase homolog (S. cerevisiae); Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions | cytochrome c oxidase assembly homolog 10 (yeast); Converts protoheme IX and farnesyl diphosphate to heme O (By similarity) | 0.678 |
OMA1 | TEPP | ENSP00000360270 | ENSP00000290871 | OMA1 zinc metallopeptidase homolog (S. cerevisiae); Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions | testis, prostate and placenta expressed | 0.600 |
SV2A | TEPP | ENSP00000358142 | ENSP00000290871 | synaptic vesicle glycoprotein 2A | testis, prostate and placenta expressed | 0.558 |
SV2B | SYT2 | ENSP00000332818 | ENSP00000356236 | synaptic vesicle glycoprotein 2B; Probably plays a role in the control of regulated secretion in neural and endocrine cells (By similarity) | synaptotagmin II; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone (By similarity) | 0.502 |
SV2B | TEPP | ENSP00000332818 | ENSP00000290871 | synaptic vesicle glycoprotein 2B; Probably plays a role in the control of regulated secretion in neural and endocrine cells (By similarity) | testis, prostate and placenta expressed | 0.795 |
SV2C | SYT2 | ENSP00000423541 | ENSP00000356236 | synaptic vesicle glycoprotein 2C; Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity) | synaptotagmin II; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone (By similarity) | 0.418 |
SV2C | TEPP | ENSP00000423541 | ENSP00000290871 | synaptic vesicle glycoprotein 2C; Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity) | testis, prostate and placenta expressed | 0.701 |
SVOP | TEPP | ENSP00000299134 | ENSP00000290871 | SV2 related protein homolog (rat) | testis, prostate and placenta expressed | 0.476 |
SYT2 | SV2B | ENSP00000356236 | ENSP00000332818 | synaptotagmin II; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone (By similarity) | synaptic vesicle glycoprotein 2B; Probably plays a role in the control of regulated secretion in neural and endocrine cells (By similarity) | 0.502 |
SYT2 | SV2C | ENSP00000356236 | ENSP00000423541 | synaptotagmin II; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone (By similarity) | synaptic vesicle glycoprotein 2C; Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity) | 0.418 |
SYT2 | TEPP | ENSP00000356236 | ENSP00000290871 | synaptotagmin II; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone (By similarity) | testis, prostate and placenta expressed | 0.505 |
TEPP | COX10 | ENSP00000290871 | ENSP00000261643 | testis, prostate and placenta expressed | cytochrome c oxidase assembly homolog 10 (yeast); Converts protoheme IX and farnesyl diphosphate to heme O (By similarity) | 0.414 |
TEPP | F12 | ENSP00000290871 | ENSP00000253496 | testis, prostate and placenta expressed | coagulation factor XII (Hageman factor); Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta- factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa | 0.549 |
TEPP | OMA1 | ENSP00000290871 | ENSP00000360270 | testis, prostate and placenta expressed | OMA1 zinc metallopeptidase homolog (S. cerevisiae); Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions | 0.600 |
TEPP | SV2A | ENSP00000290871 | ENSP00000358142 | testis, prostate and placenta expressed | synaptic vesicle glycoprotein 2A | 0.558 |
TEPP | SV2B | ENSP00000290871 | ENSP00000332818 | testis, prostate and placenta expressed | synaptic vesicle glycoprotein 2B; Probably plays a role in the control of regulated secretion in neural and endocrine cells (By similarity) | 0.795 |
TEPP | SV2C | ENSP00000290871 | ENSP00000423541 | testis, prostate and placenta expressed | synaptic vesicle glycoprotein 2C; Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity) | 0.701 |