SHF protein (Homo sapiens) - STRING network view

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SHF

Src homology 2 domain containing F; Adapter protein which may play a role in the regulation of apoptosis in response to PDGF (423 aa)

Predicted Functional Partners:

PDGFRA

0.955

PPAN

0.870

ALK

0.804

PTGFR

0.533

NTPCR

0.511

MKS1

0.485

TPPP3

0.474

MPV17

0.447

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALK	SHF	ENSP00000373700	ENSP00000290894	anaplastic lymphoma receptor tyrosine kinase; Neuronal orphan receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 [...]	Src homology 2 domain containing F; Adapter protein which may play a role in the regulation of apoptosis in response to PDGF	0.804
MKS1	SHF	ENSP00000376827	ENSP00000290894	Meckel syndrome, type 1; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Required for cell branching morphology	Src homology 2 domain containing F; Adapter protein which may play a role in the regulation of apoptosis in response to PDGF	0.485
MPV17	SHF	ENSP00000233545	ENSP00000290894	MpV17 mitochondrial inner membrane protein; Involved in mitochondria homeostasis. May be involved in the metabolism of reactive oxygen species and control of oxidative phosphorylation and mitochondrial DNA (mtDNA) maintenance	Src homology 2 domain containing F; Adapter protein which may play a role in the regulation of apoptosis in response to PDGF	0.447
NTPCR	SHF	ENSP00000355587	ENSP00000290894	nucleoside-triphosphatase, cancer-related; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency	Src homology 2 domain containing F; Adapter protein which may play a role in the regulation of apoptosis in response to PDGF	0.511
PDGFRA	SHF	ENSP00000257290	ENSP00000290894	platelet-derived growth factor receptor, alpha polypeptide; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining th [...]	Src homology 2 domain containing F; Adapter protein which may play a role in the regulation of apoptosis in response to PDGF	0.955
PPAN	SHF	ENSP00000450710	ENSP00000290894	peter pan homolog (Drosophila); Receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and adenylyl cyclase second messenger systems. Not activated by UTP or UDP	Src homology 2 domain containing F; Adapter protein which may play a role in the regulation of apoptosis in response to PDGF	0.870
PTGFR	SHF	ENSP00000359793	ENSP00000290894	prostaglandin F receptor (FP); Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity)	Src homology 2 domain containing F; Adapter protein which may play a role in the regulation of apoptosis in response to PDGF	0.533
SHF	ALK	ENSP00000290894	ENSP00000373700	Src homology 2 domain containing F; Adapter protein which may play a role in the regulation of apoptosis in response to PDGF	anaplastic lymphoma receptor tyrosine kinase; Neuronal orphan receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 [...]	0.804
SHF	MKS1	ENSP00000290894	ENSP00000376827	Src homology 2 domain containing F; Adapter protein which may play a role in the regulation of apoptosis in response to PDGF	Meckel syndrome, type 1; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Required for cell branching morphology	0.485
SHF	MPV17	ENSP00000290894	ENSP00000233545	Src homology 2 domain containing F; Adapter protein which may play a role in the regulation of apoptosis in response to PDGF	MpV17 mitochondrial inner membrane protein; Involved in mitochondria homeostasis. May be involved in the metabolism of reactive oxygen species and control of oxidative phosphorylation and mitochondrial DNA (mtDNA) maintenance	0.447
SHF	NTPCR	ENSP00000290894	ENSP00000355587	Src homology 2 domain containing F; Adapter protein which may play a role in the regulation of apoptosis in response to PDGF	nucleoside-triphosphatase, cancer-related; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency	0.511
SHF	PDGFRA	ENSP00000290894	ENSP00000257290	Src homology 2 domain containing F; Adapter protein which may play a role in the regulation of apoptosis in response to PDGF	platelet-derived growth factor receptor, alpha polypeptide; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining th [...]	0.955
SHF	PPAN	ENSP00000290894	ENSP00000450710	Src homology 2 domain containing F; Adapter protein which may play a role in the regulation of apoptosis in response to PDGF	peter pan homolog (Drosophila); Receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and adenylyl cyclase second messenger systems. Not activated by UTP or UDP	0.870
SHF	PTGFR	ENSP00000290894	ENSP00000359793	Src homology 2 domain containing F; Adapter protein which may play a role in the regulation of apoptosis in response to PDGF	prostaglandin F receptor (FP); Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity)	0.533
SHF	TPPP3	ENSP00000290894	ENSP00000290942	Src homology 2 domain containing F; Adapter protein which may play a role in the regulation of apoptosis in response to PDGF	tubulin polymerization-promoting protein family member 3; Binds tubulin and has microtubule bundling activity. May play a role in cell proliferation and mitosis	0.474
TPPP3	SHF	ENSP00000290942	ENSP00000290894	tubulin polymerization-promoting protein family member 3; Binds tubulin and has microtubule bundling activity. May play a role in cell proliferation and mitosis	Src homology 2 domain containing F; Adapter protein which may play a role in the regulation of apoptosis in response to PDGF	0.474

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