PIP protein (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Size

small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

PIP

prolactin-induced protein (146 aa)

Predicted Functional Partners:

AZGP1

0.939

KEL

0.757

USPL1

0.741

USP25

0.740

KRT7

0.726

USP21

0.662

LCN1

0.635

ACHE

0.609

EDN3

0.604

CD4

0.602

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACHE	KEL	ENSP00000303211	ENSP00000347409	acetylcholinesterase	Kell blood group, metallo-endopeptidase; Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3	0.457
ACHE	PIP	ENSP00000303211	ENSP00000291009	acetylcholinesterase	prolactin-induced protein	0.609
AZGP1	PIP	ENSP00000292401	ENSP00000291009	alpha-2-glycoprotein 1, zinc-binding; Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids	prolactin-induced protein	0.939
CD4	PIP	ENSP00000011653	ENSP00000291009	CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts	prolactin-induced protein	0.602
EDN3	KEL	ENSP00000337128	ENSP00000347409	endothelin 3; Endothelins are endothelium-derived vasoconstrictor peptides	Kell blood group, metallo-endopeptidase; Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3	0.826
EDN3	PIP	ENSP00000337128	ENSP00000291009	endothelin 3; Endothelins are endothelium-derived vasoconstrictor peptides	prolactin-induced protein	0.604
KEL	ACHE	ENSP00000347409	ENSP00000303211	Kell blood group, metallo-endopeptidase; Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3	acetylcholinesterase	0.457
KEL	EDN3	ENSP00000347409	ENSP00000337128	Kell blood group, metallo-endopeptidase; Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3	endothelin 3; Endothelins are endothelium-derived vasoconstrictor peptides	0.826
KEL	PIP	ENSP00000347409	ENSP00000291009	Kell blood group, metallo-endopeptidase; Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3	prolactin-induced protein	0.757
KRT7	PIP	ENSP00000329243	ENSP00000291009	keratin 7; Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7)	prolactin-induced protein	0.726
LCN1	PIP	ENSP00000263598	ENSP00000291009	lipocalin 1; Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket	prolactin-induced protein	0.635
PIP	ACHE	ENSP00000291009	ENSP00000303211	prolactin-induced protein	acetylcholinesterase	0.609
PIP	AZGP1	ENSP00000291009	ENSP00000292401	prolactin-induced protein	alpha-2-glycoprotein 1, zinc-binding; Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids	0.939
PIP	CD4	ENSP00000291009	ENSP00000011653	prolactin-induced protein	CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts	0.602
PIP	EDN3	ENSP00000291009	ENSP00000337128	prolactin-induced protein	endothelin 3; Endothelins are endothelium-derived vasoconstrictor peptides	0.604
PIP	KEL	ENSP00000291009	ENSP00000347409	prolactin-induced protein	Kell blood group, metallo-endopeptidase; Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3	0.757
PIP	KRT7	ENSP00000291009	ENSP00000329243	prolactin-induced protein	keratin 7; Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7)	0.726
PIP	LCN1	ENSP00000291009	ENSP00000263598	prolactin-induced protein	lipocalin 1; Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket	0.635
PIP	USP21	ENSP00000291009	ENSP00000289865	prolactin-induced protein	ubiquitin specific peptidase 21; Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at ’Lys-4’, resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates	0.662
PIP	USP25	ENSP00000291009	ENSP00000285679	prolactin-induced protein	ubiquitin specific peptidase 25; Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both ’Lys-48’- and ’Lys-63’-linked tetraubiquitin chains	0.740

page 1 of 2

Experiments

Cooccurrence

Textmining

Neighborhood

Databases

Fusion

Coexpression

© STRING Consortium 2017

Credits

Access

Info

About