node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BIRC5 | CALM3 | ENSP00000301633 | ENSP00000291295 | baculoviral IAP repeat containing 5 | calmodulin 3 (phosphorylase kinase, delta) | 0.904 |
BIRC5 | CAPN6 | ENSP00000301633 | ENSP00000317214 | baculoviral IAP repeat containing 5 | calpain 6; Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues (By similarity) | 0.902 |
BIRC5 | CDK1 | ENSP00000301633 | ENSP00000378699 | baculoviral IAP repeat containing 5 | cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl- xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, G [...] | 0.999 |
BIRC5 | CUL3 | ENSP00000301633 | ENSP00000264414 | baculoviral IAP repeat containing 5 | cullin 3; Core component of multiple cullin-RING-based BCR (BTB- CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the BCR comple [...] | 0.917 |
BIRC5 | HDAC3 | ENSP00000301633 | ENSP00000302967 | baculoviral IAP repeat containing 5 | histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required [...] | 0.923 |
BIRC5 | KIF18A | ENSP00000301633 | ENSP00000263181 | baculoviral IAP repeat containing 5 | kinesin family member 18A; Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression | 0.919 |
BIRC5 | PAFAH1B1 | ENSP00000301633 | ENSP00000380378 | baculoviral IAP repeat containing 5 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa); Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet- activating factor (PAF) by removing the acetyl group at the SN-2 position (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated [...] | 0.916 |
BIRC5 | TUBG1 | ENSP00000301633 | ENSP00000251413 | baculoviral IAP repeat containing 5 | tubulin, gamma 1; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation | 0.914 |
BIRC5 | TUBGCP3 | ENSP00000301633 | ENSP00000261965 | baculoviral IAP repeat containing 5 | tubulin, gamma complex associated protein 3; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome | 0.900 |
CALM3 | BIRC5 | ENSP00000291295 | ENSP00000301633 | calmodulin 3 (phosphorylase kinase, delta) | baculoviral IAP repeat containing 5 | 0.904 |
CALM3 | CAPN6 | ENSP00000291295 | ENSP00000317214 | calmodulin 3 (phosphorylase kinase, delta) | calpain 6; Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues (By similarity) | 0.909 |
CALM3 | CDK1 | ENSP00000291295 | ENSP00000378699 | calmodulin 3 (phosphorylase kinase, delta) | cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl- xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, G [...] | 0.908 |
CALM3 | CUL3 | ENSP00000291295 | ENSP00000264414 | calmodulin 3 (phosphorylase kinase, delta) | cullin 3; Core component of multiple cullin-RING-based BCR (BTB- CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the BCR comple [...] | 0.905 |
CALM3 | HDAC3 | ENSP00000291295 | ENSP00000302967 | calmodulin 3 (phosphorylase kinase, delta) | histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required [...] | 0.921 |
CALM3 | KIF18A | ENSP00000291295 | ENSP00000263181 | calmodulin 3 (phosphorylase kinase, delta) | kinesin family member 18A; Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression | 0.913 |
CALM3 | MYH14 | ENSP00000291295 | ENSP00000262269 | calmodulin 3 (phosphorylase kinase, delta) | myosin, heavy chain 14, non-muscle | 0.911 |
CALM3 | PAFAH1B1 | ENSP00000291295 | ENSP00000380378 | calmodulin 3 (phosphorylase kinase, delta) | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa); Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet- activating factor (PAF) by removing the acetyl group at the SN-2 position (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated [...] | 0.904 |
CALM3 | TUBG1 | ENSP00000291295 | ENSP00000251413 | calmodulin 3 (phosphorylase kinase, delta) | tubulin, gamma 1; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation | 0.920 |
CALM3 | TUBGCP3 | ENSP00000291295 | ENSP00000261965 | calmodulin 3 (phosphorylase kinase, delta) | tubulin, gamma complex associated protein 3; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome | 0.904 |
CAPN6 | BIRC5 | ENSP00000317214 | ENSP00000301633 | calpain 6; Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues (By similarity) | baculoviral IAP repeat containing 5 | 0.902 |