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NPR1 NPR1 ADCY8 ADCY8 ADCY4 ADCY4 ADCY5 ADCY5 ADCY2 ADCY2 ADCY3 ADCY3 PDE9A PDE9A ADCY7 ADCY7 NPR2 NPR2 ADCY6 ADCY6 GUCY2C GUCY2C
"PDE9A" - phosphodiesterase 9A in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PDE9Aphosphodiesterase 9A (593 aa)    
Predicted Functional Partners:
ADCY5
adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase (1261 aa)
       score_image score_image score_image score_image   0.964
ADCY2
adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase (1091 aa)
       score_image score_image score_image score_image   0.964
ADCY7
adenylate cyclase 7; This is a membrane-bound, calcium-inhibitable adenylyl cyclase (1080 aa)
       score_image score_image score_image score_image   0.963
ADCY6
adenylate cyclase 6; Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity) (1168 aa)
       score_image score_image score_image score_image   0.962
ADCY4
adenylate cyclase 4; This is a membrane-bound, calmodulin-insensitive adenylyl cyclase (By similarity) (1077 aa)
       score_image score_image score_image score_image   0.962
ADCY8
adenylate cyclase 8 (brain); This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity) (1251 aa)
       score_image score_image score_image score_image   0.962
ADCY3
adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration (1144 aa)
       score_image score_image score_image score_image   0.962
NPR1
natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A); Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand (1061 aa)
       score_image score_image score_image score_image   0.955
NPR2
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) (1047 aa)
       score_image score_image score_image score_image   0.955
GUCY2C
guanylate cyclase 2C (heat stable enterotoxin receptor); Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptides guanylin and uroguanylin (1073 aa)
       score_image score_image score_image score_image   0.955
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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