| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| HORMAD2 | HSF2BP | ENSP00000336984 | ENSP00000291560 | HORMA domain containing 2; Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint- required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex bod [...] | heat shock transcription factor 2 binding protein; May be involved in modulating HSF2 activation in testis | 0.477 |
| HORMAD2 | SMC1B | ENSP00000336984 | ENSP00000350036 | HORMA domain containing 2; Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint- required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex bod [...] | structural maintenance of chromosomes 1B; Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the compl [...] | 0.595 |
| HSF1 | HSF2 | ENSP00000431512 | ENSP00000357440 | heat shock transcription factor 1; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked | heat shock transcription factor 2; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked | 0.712 |
| HSF1 | HSF2BP | ENSP00000431512 | ENSP00000291560 | heat shock transcription factor 1; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked | heat shock transcription factor 2 binding protein; May be involved in modulating HSF2 activation in testis | 0.606 |
| HSF1 | UBE2I | ENSP00000431512 | ENSP00000324897 | heat shock transcription factor 1; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked | ubiquitin-conjugating enzyme E2I; Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Can catalyze the formation of poly- SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at ’Lys-386’ (By similarity) | 0.465 |
| HSF2 | HSF1 | ENSP00000357440 | ENSP00000431512 | heat shock transcription factor 2; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked | heat shock transcription factor 1; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked | 0.712 |
| HSF2 | HSF2BP | ENSP00000357440 | ENSP00000291560 | heat shock transcription factor 2; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked | heat shock transcription factor 2 binding protein; May be involved in modulating HSF2 activation in testis | 0.977 |
| HSF2 | UBE2I | ENSP00000357440 | ENSP00000324897 | heat shock transcription factor 2; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked | ubiquitin-conjugating enzyme E2I; Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Can catalyze the formation of poly- SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at ’Lys-386’ (By similarity) | 0.902 |
| HSF2BP | HORMAD2 | ENSP00000291560 | ENSP00000336984 | heat shock transcription factor 2 binding protein; May be involved in modulating HSF2 activation in testis | HORMA domain containing 2; Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint- required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex bod [...] | 0.477 |
| HSF2BP | HSF1 | ENSP00000291560 | ENSP00000431512 | heat shock transcription factor 2 binding protein; May be involved in modulating HSF2 activation in testis | heat shock transcription factor 1; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked | 0.606 |
| HSF2BP | HSF2 | ENSP00000291560 | ENSP00000357440 | heat shock transcription factor 2 binding protein; May be involved in modulating HSF2 activation in testis | heat shock transcription factor 2; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked | 0.977 |
| HSF2BP | ITSN1 | ENSP00000291560 | ENSP00000370719 | heat shock transcription factor 2 binding protein; May be involved in modulating HSF2 activation in testis | intersectin 1 (SH3 domain protein); Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1 | 0.470 |
| HSF2BP | RRP1B | ENSP00000291560 | ENSP00000339145 | heat shock transcription factor 2 binding protein; May be involved in modulating HSF2 activation in testis | ribosomal RNA processing 1 homolog B (S. cerevisiae) | 0.448 |
| HSF2BP | SMC1B | ENSP00000291560 | ENSP00000350036 | heat shock transcription factor 2 binding protein; May be involved in modulating HSF2 activation in testis | structural maintenance of chromosomes 1B; Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the compl [...] | 0.424 |
| HSF2BP | UBE2I | ENSP00000291560 | ENSP00000324897 | heat shock transcription factor 2 binding protein; May be involved in modulating HSF2 activation in testis | ubiquitin-conjugating enzyme E2I; Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Can catalyze the formation of poly- SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at ’Lys-386’ (By similarity) | 0.573 |
| ITSN1 | HSF2BP | ENSP00000370719 | ENSP00000291560 | intersectin 1 (SH3 domain protein); Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1 | heat shock transcription factor 2 binding protein; May be involved in modulating HSF2 activation in testis | 0.470 |
| RRP1B | HSF2BP | ENSP00000339145 | ENSP00000291560 | ribosomal RNA processing 1 homolog B (S. cerevisiae) | heat shock transcription factor 2 binding protein; May be involved in modulating HSF2 activation in testis | 0.448 |
| SMC1B | HORMAD2 | ENSP00000350036 | ENSP00000336984 | structural maintenance of chromosomes 1B; Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the compl [...] | HORMA domain containing 2; Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint- required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex bod [...] | 0.595 |
| SMC1B | HSF2BP | ENSP00000350036 | ENSP00000291560 | structural maintenance of chromosomes 1B; Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the compl [...] | heat shock transcription factor 2 binding protein; May be involved in modulating HSF2 activation in testis | 0.424 |
| SMC1B | UBE2I | ENSP00000350036 | ENSP00000324897 | structural maintenance of chromosomes 1B; Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the compl [...] | ubiquitin-conjugating enzyme E2I; Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Can catalyze the formation of poly- SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at ’Lys-386’ (By similarity) | 0.909 |
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