node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AOX1 | PDXK | ENSP00000363832 | ENSP00000291565 | aldehyde oxidase 1 | pyridoxal (pyridoxine, vitamin B6) kinase; Required for synthesis of pyridoxal-5-phosphate from vitamin B6 | 0.900 |
AOX1 | PDXP | ENSP00000363832 | ENSP00000215904 | aldehyde oxidase 1 | pyridoxal (pyridoxine, vitamin B6) phosphatase; Protein serine phosphatase that dephosphorylates ’Ser-3’ in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho- tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5’-phosphate (PLP), pyridoxine 5’-phosphate (PMP) and pyridoxine 5’-phosphate (PNP), with [...] | 0.900 |
AOX1 | PHOSPHO2 | ENSP00000363832 | ENSP00000352782 | aldehyde oxidase 1 | phosphatase, orphan 2; Phosphatase that has high activity toward pyridoxal 5’- phosphate (PLP). Also active at much lower level toward pyrophosphate, phosphoethanolamine (PEA), phosphocholine (PCho), phospho-l-tyrosine, fructose-6-phosphate, p-nitrophenyl phosphate, and h-glycerophosphate | 0.900 |
AOX1 | PNPO | ENSP00000363832 | ENSP00000225573 | aldehyde oxidase 1 | pyridoxamine 5’-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5’- phosphate (PNP) or pyridoxamine 5’-phosphate (PMP) into pyridoxal 5’-phosphate (PLP) | 0.900 |
DBP | PDXK | ENSP00000222122 | ENSP00000291565 | D site of albumin promoter (albumin D-box) binding protein; This transcriptional activator recognizes and binds to the sequence 5’-RTTAYGTAAY-3’ found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation | pyridoxal (pyridoxine, vitamin B6) kinase; Required for synthesis of pyridoxal-5-phosphate from vitamin B6 | 0.632 |
DBP | TEF | ENSP00000222122 | ENSP00000266304 | D site of albumin promoter (albumin D-box) binding protein; This transcriptional activator recognizes and binds to the sequence 5’-RTTAYGTAAY-3’ found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation | thyrotrophic embryonic factor; Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5’- [TC][AG][AG]TTA[TC][AG]-3’ | 0.598 |
PDXK | AOX1 | ENSP00000291565 | ENSP00000363832 | pyridoxal (pyridoxine, vitamin B6) kinase; Required for synthesis of pyridoxal-5-phosphate from vitamin B6 | aldehyde oxidase 1 | 0.900 |
PDXK | DBP | ENSP00000291565 | ENSP00000222122 | pyridoxal (pyridoxine, vitamin B6) kinase; Required for synthesis of pyridoxal-5-phosphate from vitamin B6 | D site of albumin promoter (albumin D-box) binding protein; This transcriptional activator recognizes and binds to the sequence 5’-RTTAYGTAAY-3’ found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation | 0.632 |
PDXK | PDXP | ENSP00000291565 | ENSP00000215904 | pyridoxal (pyridoxine, vitamin B6) kinase; Required for synthesis of pyridoxal-5-phosphate from vitamin B6 | pyridoxal (pyridoxine, vitamin B6) phosphatase; Protein serine phosphatase that dephosphorylates ’Ser-3’ in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho- tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5’-phosphate (PLP), pyridoxine 5’-phosphate (PMP) and pyridoxine 5’-phosphate (PNP), with [...] | 0.844 |
PDXK | PHOSPHO2 | ENSP00000291565 | ENSP00000352782 | pyridoxal (pyridoxine, vitamin B6) kinase; Required for synthesis of pyridoxal-5-phosphate from vitamin B6 | phosphatase, orphan 2; Phosphatase that has high activity toward pyridoxal 5’- phosphate (PLP). Also active at much lower level toward pyrophosphate, phosphoethanolamine (PEA), phosphocholine (PCho), phospho-l-tyrosine, fructose-6-phosphate, p-nitrophenyl phosphate, and h-glycerophosphate | 0.800 |
PDXK | PNPO | ENSP00000291565 | ENSP00000225573 | pyridoxal (pyridoxine, vitamin B6) kinase; Required for synthesis of pyridoxal-5-phosphate from vitamin B6 | pyridoxamine 5’-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5’- phosphate (PNP) or pyridoxamine 5’-phosphate (PMP) into pyridoxal 5’-phosphate (PLP) | 0.986 |
PDXK | TEF | ENSP00000291565 | ENSP00000266304 | pyridoxal (pyridoxine, vitamin B6) kinase; Required for synthesis of pyridoxal-5-phosphate from vitamin B6 | thyrotrophic embryonic factor; Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5’- [TC][AG][AG]TTA[TC][AG]-3’ | 0.687 |
PDXK | TRAPPC4 | ENSP00000291565 | ENSP00000436005 | pyridoxal (pyridoxine, vitamin B6) kinase; Required for synthesis of pyridoxal-5-phosphate from vitamin B6 | trafficking protein particle complex 4; May play a role in vesicular transport from endoplasmic reticulum to Golgi | 0.561 |
PDXK | TSPO | ENSP00000291565 | ENSP00000328973 | pyridoxal (pyridoxine, vitamin B6) kinase; Required for synthesis of pyridoxal-5-phosphate from vitamin B6 | translocator protein (18kDa); Responsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely to comprise binding domains for benzodiazepines and isoquinoline carboxamides. May play a role in the transport of porphyrins and heme. Plays a role in the transport of cholesterol across mitochondrial membranes in steroidogenic cells (By similarity) | 0.580 |
PDXK | UBC | ENSP00000291565 | ENSP00000344818 | pyridoxal (pyridoxine, vitamin B6) kinase; Required for synthesis of pyridoxal-5-phosphate from vitamin B6 | ubiquitin C | 0.953 |
PDXK | WDR4 | ENSP00000291565 | ENSP00000328671 | pyridoxal (pyridoxine, vitamin B6) kinase; Required for synthesis of pyridoxal-5-phosphate from vitamin B6 | WD repeat domain 4; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational change of the catalytic subunit | 0.583 |
PDXP | AOX1 | ENSP00000215904 | ENSP00000363832 | pyridoxal (pyridoxine, vitamin B6) phosphatase; Protein serine phosphatase that dephosphorylates ’Ser-3’ in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho- tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5’-phosphate (PLP), pyridoxine 5’-phosphate (PMP) and pyridoxine 5’-phosphate (PNP), with [...] | aldehyde oxidase 1 | 0.900 |
PDXP | PDXK | ENSP00000215904 | ENSP00000291565 | pyridoxal (pyridoxine, vitamin B6) phosphatase; Protein serine phosphatase that dephosphorylates ’Ser-3’ in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho- tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5’-phosphate (PLP), pyridoxine 5’-phosphate (PMP) and pyridoxine 5’-phosphate (PNP), with [...] | pyridoxal (pyridoxine, vitamin B6) kinase; Required for synthesis of pyridoxal-5-phosphate from vitamin B6 | 0.844 |
PDXP | PHOSPHO2 | ENSP00000215904 | ENSP00000352782 | pyridoxal (pyridoxine, vitamin B6) phosphatase; Protein serine phosphatase that dephosphorylates ’Ser-3’ in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho- tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5’-phosphate (PLP), pyridoxine 5’-phosphate (PMP) and pyridoxine 5’-phosphate (PNP), with [...] | phosphatase, orphan 2; Phosphatase that has high activity toward pyridoxal 5’- phosphate (PLP). Also active at much lower level toward pyrophosphate, phosphoethanolamine (PEA), phosphocholine (PCho), phospho-l-tyrosine, fructose-6-phosphate, p-nitrophenyl phosphate, and h-glycerophosphate | 0.800 |
PDXP | PNPO | ENSP00000215904 | ENSP00000225573 | pyridoxal (pyridoxine, vitamin B6) phosphatase; Protein serine phosphatase that dephosphorylates ’Ser-3’ in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho- tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5’-phosphate (PLP), pyridoxine 5’-phosphate (PMP) and pyridoxine 5’-phosphate (PNP), with [...] | pyridoxamine 5’-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5’- phosphate (PNP) or pyridoxamine 5’-phosphate (PMP) into pyridoxal 5’-phosphate (PLP) | 0.921 |