Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | FAM207A | family with sequence similarity 207, member A (230 aa) | ||||||||||||
Predicted Functional Partners:
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 | FAM165B | family with sequence similarity 165, member B (58 aa) |
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0.622 | ||||||||||
 | DHX37 | DEAH (Asp-Glu-Ala-His) box polypeptide 37 (1157 aa) |
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0.584 | ||||||||||
 | C21orf58 | chromosome 21 open reading frame 58 (322 aa) |
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0.567 | ||||||||||
 | DCAF5 | DDB1 and CUL4 associated factor 5; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (942 aa) |
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0.548 | ||||||||||
 | C6orf203 | chromosome 6 open reading frame 203 (245 aa) |
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0.531 | ||||||||||
 | RIOK2 | RIO kinase 2 (yeast) (552 aa) |
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0.497 | |||||||||
 | LTV1 | LTV1 homolog (S. cerevisiae) (475 aa) |
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0.491 | |||||||||
 | UBC | ubiquitin C (685 aa) |
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0.483 | ||||||||||
 | NOB1 | NIN1/RPN12 binding protein 1 homolog (S. cerevisiae); May play a role in mRNA degradation (412 aa) |
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0.470 | |||||||||
 | TSR1 | TSR1, 20S rRNA accumulation, homolog (S. cerevisiae); Required during maturation of the 40S ribosomal subunit in the nucleolus (By similarity) (804 aa) |
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0.470 | |||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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