Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
|
Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | C21orf58 | chromosome 21 open reading frame 58 (322 aa) | ||||||||||||
Predicted Functional Partners:
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 | PRDM15 | PR domain containing 15; May be involved in transcriptional regulation (1507 aa) |
 |
0.592 | ||||||||||
 | YBEY | ybeY metallopeptidase (putative) (167 aa) |
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0.580 | ||||||||||
 | FAM165B | family with sequence similarity 165, member B (58 aa) |
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0.580 | ||||||||||
 | FAM207A | family with sequence similarity 207, member A (230 aa) |
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0.567 | ||||||||||
 | FAM124A | family with sequence similarity 124A (582 aa) |
|
0.532 | ||||||||||
 | KLHDC7A | kelch domain containing 7A (777 aa) |
|
0.509 | ||||||||||
 | SLC22A18AS | solute carrier family 22 (organic cation transporter), member 18 antisense (253 aa) |
|
0.508 | ||||||||||
 | C21orf7 | chromosome 21 open reading frame 7 (242 aa) |
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0.505 | ||||||||||
 | C6orf203 | chromosome 6 open reading frame 203 (245 aa) |
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0.504 | ||||||||||
 | PPHLN1 | periphilin 1; Involved in epithelial differentiation and contributes to epidermal integrity and barrier formation (458 aa) |
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0.504 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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