node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APP | FCN2 | ENSP00000284981 | ENSP00000291744 | amyloid beta (A4) precursor protein | ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin); May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc- binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region | 0.806 |
APP | LRP1 | ENSP00000284981 | ENSP00000243077 | amyloid beta (A4) precursor protein | low density lipoprotein receptor-related protein 1; Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission | 0.976 |
C1R | C1S | ENSP00000290575 | ENSP00000328173 | complement component 1, r subcomponent | complement component 1, s subcomponent | 0.985 |
C1R | C4B | ENSP00000290575 | ENSP00000415941 | complement component 1, r subcomponent | complement component 4B (Chido blood group) | 0.951 |
C1R | CRP | ENSP00000290575 | ENSP00000255030 | complement component 1, r subcomponent | C-reactive protein, pentraxin-related; Displays several functions associated with host defense- it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells | 0.902 |
C1R | FCN2 | ENSP00000290575 | ENSP00000291744 | complement component 1, r subcomponent | ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin); May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc- binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region | 0.569 |
C1R | LRP1 | ENSP00000290575 | ENSP00000243077 | complement component 1, r subcomponent | low density lipoprotein receptor-related protein 1; Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission | 0.840 |
C1S | C1R | ENSP00000328173 | ENSP00000290575 | complement component 1, s subcomponent | complement component 1, r subcomponent | 0.985 |
C1S | C4B | ENSP00000328173 | ENSP00000415941 | complement component 1, s subcomponent | complement component 4B (Chido blood group) | 0.846 |
C1S | CRP | ENSP00000328173 | ENSP00000255030 | complement component 1, s subcomponent | C-reactive protein, pentraxin-related; Displays several functions associated with host defense- it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells | 0.900 |
C1S | FCN2 | ENSP00000328173 | ENSP00000291744 | complement component 1, s subcomponent | ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin); May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc- binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region | 0.634 |
C1S | LRP1 | ENSP00000328173 | ENSP00000243077 | complement component 1, s subcomponent | low density lipoprotein receptor-related protein 1; Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission | 0.850 |
C1S | MBL2 | ENSP00000328173 | ENSP00000363079 | complement component 1, s subcomponent | mannose-binding lectin (protein C) 2, soluble; Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA | 0.445 |
C4B | C1R | ENSP00000415941 | ENSP00000290575 | complement component 4B (Chido blood group) | complement component 1, r subcomponent | 0.951 |
C4B | C1S | ENSP00000415941 | ENSP00000328173 | complement component 4B (Chido blood group) | complement component 1, s subcomponent | 0.846 |
C4B | FCN2 | ENSP00000415941 | ENSP00000291744 | complement component 4B (Chido blood group) | ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin); May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc- binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region | 0.560 |
C4B | MASP1 | ENSP00000415941 | ENSP00000296280 | complement component 4B (Chido blood group) | mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) | 0.934 |
C4B | MASP2 | ENSP00000415941 | ENSP00000383690 | complement component 4B (Chido blood group) | mannan-binding lectin serine peptidase 2 | 0.957 |
CRP | C1R | ENSP00000255030 | ENSP00000290575 | C-reactive protein, pentraxin-related; Displays several functions associated with host defense- it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells | complement component 1, r subcomponent | 0.902 |
CRP | C1S | ENSP00000255030 | ENSP00000328173 | C-reactive protein, pentraxin-related; Displays several functions associated with host defense- it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells | complement component 1, s subcomponent | 0.900 |