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FGF5 FGF5 FGF3 FGF3 FGF17 FGF17 FGF1 FGF1 FGFR4 FGFR4 FGF2 FGF2 FGF6 FGF6 FGF19 FGF19 KLB KLB FGF9 FGF9 FGF4 FGF4
"FGFR4" - fibroblast growth factor receptor 4 in Homo sapiens
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FGFR4fibroblast growth factor receptor 4; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of [...] (802 aa)    
Predicted Functional Partners:
FGF9
fibroblast growth factor 9 (glia-activating factor); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors (208 aa)
        score_image score_image score_image   0.999
FGF4
fibroblast growth factor 4; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis (206 aa)
        score_image score_image score_image   0.999
FGF1
fibroblast growth factor 1 (acidic); Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro (155 aa)
        score_image score_image score_image   0.999
FGF2
fibroblast growth factor 2 (basic) (288 aa)
        score_image score_image score_image   0.999
FGF5
fibroblast growth factor 5; Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (By similarity) (268 aa)
        score_image score_image score_image   0.999
FGF3
fibroblast growth factor 3; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development (239 aa)
        score_image   score_image   0.999
FGF19
fibroblast growth factor 19; Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4 (216 aa)
        score_image score_image score_image   0.998
FGF17
fibroblast growth factor 17; Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development (216 aa)
        score_image score_image score_image   0.997
FGF6
fibroblast growth factor 6; Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration (208 aa)
        score_image score_image score_image   0.997
KLB
klotho beta; Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity) (1044 aa)
        score_image score_image score_image   0.995
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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