| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABTB1 | GJB5 | ENSP00000232744 | ENSP00000340811 | ankyrin repeat and BTB (POZ) domain containing 1; May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes | gap junction protein, beta 5, 31.1kDa; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell | 0.598 |
| ABTB1 | LY6E | ENSP00000232744 | ENSP00000292494 | ankyrin repeat and BTB (POZ) domain containing 1; May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes | lymphocyte antigen 6 complex, locus E | 0.584 |
| CD247 | LY6E | ENSP00000354782 | ENSP00000292494 | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | lymphocyte antigen 6 complex, locus E | 0.576 |
| CD55 | CD59 | ENSP00000316333 | ENSP00000340210 | CD55 molecule, decay accelerating factor for complement (Cromer blood group); This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade | CD59 molecule, complement regulatory protein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase | 0.901 |
| CD55 | LY6E | ENSP00000316333 | ENSP00000292494 | CD55 molecule, decay accelerating factor for complement (Cromer blood group); This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade | lymphocyte antigen 6 complex, locus E | 0.562 |
| CD59 | CD55 | ENSP00000340210 | ENSP00000316333 | CD59 molecule, complement regulatory protein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase | CD55 molecule, decay accelerating factor for complement (Cromer blood group); This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade | 0.901 |
| CD59 | LY6E | ENSP00000340210 | ENSP00000292494 | CD59 molecule, complement regulatory protein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase | lymphocyte antigen 6 complex, locus E | 0.754 |
| FCGR2B | LY6E | ENSP00000351497 | ENSP00000292494 | Fc fragment of IgG, low affinity IIb, receptor (CD32); Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B- cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis | lymphocyte antigen 6 complex, locus E | 0.576 |
| GJB5 | ABTB1 | ENSP00000340811 | ENSP00000232744 | gap junction protein, beta 5, 31.1kDa; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell | ankyrin repeat and BTB (POZ) domain containing 1; May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes | 0.598 |
| GJB5 | LY6E | ENSP00000340811 | ENSP00000292494 | gap junction protein, beta 5, 31.1kDa; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell | lymphocyte antigen 6 complex, locus E | 0.633 |
| GML | LY6E | ENSP00000220940 | ENSP00000292494 | glycosylphosphatidylinositol anchored molecule like; May play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage | lymphocyte antigen 6 complex, locus E | 0.888 |
| GML | LY6H | ENSP00000220940 | ENSP00000342711 | glycosylphosphatidylinositol anchored molecule like; May play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage | lymphocyte antigen 6 complex, locus H | 0.868 |
| IFNA1 | LY6E | ENSP00000276927 | ENSP00000292494 | interferon, alpha 1 | lymphocyte antigen 6 complex, locus E | 0.817 |
| LY6E | ABTB1 | ENSP00000292494 | ENSP00000232744 | lymphocyte antigen 6 complex, locus E | ankyrin repeat and BTB (POZ) domain containing 1; May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes | 0.584 |
| LY6E | CD247 | ENSP00000292494 | ENSP00000354782 | lymphocyte antigen 6 complex, locus E | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | 0.576 |
| LY6E | CD55 | ENSP00000292494 | ENSP00000316333 | lymphocyte antigen 6 complex, locus E | CD55 molecule, decay accelerating factor for complement (Cromer blood group); This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade | 0.562 |
| LY6E | CD59 | ENSP00000292494 | ENSP00000340210 | lymphocyte antigen 6 complex, locus E | CD59 molecule, complement regulatory protein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase | 0.754 |
| LY6E | FCGR2B | ENSP00000292494 | ENSP00000351497 | lymphocyte antigen 6 complex, locus E | Fc fragment of IgG, low affinity IIb, receptor (CD32); Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B- cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis | 0.576 |
| LY6E | GJB5 | ENSP00000292494 | ENSP00000340811 | lymphocyte antigen 6 complex, locus E | gap junction protein, beta 5, 31.1kDa; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell | 0.633 |
| LY6E | GML | ENSP00000292494 | ENSP00000220940 | lymphocyte antigen 6 complex, locus E | glycosylphosphatidylinositol anchored molecule like; May play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage | 0.888 |
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