| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKAP9 | CAMK2A | ENSP00000348573 | ENSP00000381412 | A kinase (PRKA) anchor protein (yotiao) 9 | calcium/calmodulin-dependent protein kinase II alpha; CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity) | 0.901 |
| AKAP9 | CAMK2B | ENSP00000348573 | ENSP00000379098 | A kinase (PRKA) anchor protein (yotiao) 9 | calcium/calmodulin-dependent protein kinase II beta | 0.900 |
| AKAP9 | CAMK2D | ENSP00000348573 | ENSP00000339740 | A kinase (PRKA) anchor protein (yotiao) 9 | calcium/calmodulin-dependent protein kinase II delta; Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart f [...] | 0.900 |
| AKAP9 | CAMK2G | ENSP00000348573 | ENSP00000319060 | A kinase (PRKA) anchor protein (yotiao) 9 | calcium/calmodulin-dependent protein kinase II gamma | 0.900 |
| AKAP9 | DLG4 | ENSP00000348573 | ENSP00000293813 | A kinase (PRKA) anchor protein (yotiao) 9 | discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) | 0.931 |
| AKAP9 | GRIN1 | ENSP00000348573 | ENSP00000360608 | A kinase (PRKA) anchor protein (yotiao) 9 | glutamate receptor, ionotropic, N-methyl D-aspartate 1 | 0.974 |
| AKAP9 | GRIN2C | ENSP00000348573 | ENSP00000293190 | A kinase (PRKA) anchor protein (yotiao) 9 | glutamate receptor, ionotropic, N-methyl D-aspartate 2C; NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine | 0.935 |
| AKAP9 | RASGRF1 | ENSP00000348573 | ENSP00000405963 | A kinase (PRKA) anchor protein (yotiao) 9 | Ras protein-specific guanine nucleotide-releasing factor 1; Promotes the exchange of Ras-bound GDP by GTP | 0.900 |
| AKAP9 | RASGRF2 | ENSP00000348573 | ENSP00000265080 | A kinase (PRKA) anchor protein (yotiao) 9 | Ras protein-specific guanine nucleotide-releasing factor 2; Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation | 0.900 |
| CAMK2A | AKAP9 | ENSP00000381412 | ENSP00000348573 | calcium/calmodulin-dependent protein kinase II alpha; CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity) | A kinase (PRKA) anchor protein (yotiao) 9 | 0.901 |
| CAMK2A | CAMK2B | ENSP00000381412 | ENSP00000379098 | calcium/calmodulin-dependent protein kinase II alpha; CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity) | calcium/calmodulin-dependent protein kinase II beta | 0.942 |
| CAMK2A | CAMK2D | ENSP00000381412 | ENSP00000339740 | calcium/calmodulin-dependent protein kinase II alpha; CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity) | calcium/calmodulin-dependent protein kinase II delta; Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart f [...] | 0.974 |
| CAMK2A | CAMK2G | ENSP00000381412 | ENSP00000319060 | calcium/calmodulin-dependent protein kinase II alpha; CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity) | calcium/calmodulin-dependent protein kinase II gamma | 0.903 |
| CAMK2A | DLG3 | ENSP00000381412 | ENSP00000363480 | calcium/calmodulin-dependent protein kinase II alpha; CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity) | discs, large homolog 3 (Drosophila); Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling | 0.729 |
| CAMK2A | DLG4 | ENSP00000381412 | ENSP00000293813 | calcium/calmodulin-dependent protein kinase II alpha; CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity) | discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) | 0.971 |
| CAMK2A | GRIN1 | ENSP00000381412 | ENSP00000360608 | calcium/calmodulin-dependent protein kinase II alpha; CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity) | glutamate receptor, ionotropic, N-methyl D-aspartate 1 | 0.982 |
| CAMK2A | GRIN2C | ENSP00000381412 | ENSP00000293190 | calcium/calmodulin-dependent protein kinase II alpha; CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity) | glutamate receptor, ionotropic, N-methyl D-aspartate 2C; NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine | 0.943 |
| CAMK2A | RASGRF1 | ENSP00000381412 | ENSP00000405963 | calcium/calmodulin-dependent protein kinase II alpha; CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity) | Ras protein-specific guanine nucleotide-releasing factor 1; Promotes the exchange of Ras-bound GDP by GTP | 0.905 |
| CAMK2A | RASGRF2 | ENSP00000381412 | ENSP00000265080 | calcium/calmodulin-dependent protein kinase II alpha; CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity) | Ras protein-specific guanine nucleotide-releasing factor 2; Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation | 0.909 |
| CAMK2B | AKAP9 | ENSP00000379098 | ENSP00000348573 | calcium/calmodulin-dependent protein kinase II beta | A kinase (PRKA) anchor protein (yotiao) 9 | 0.900 |
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