node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALB | CYGB | ENSP00000295897 | ENSP00000293230 | albumin | cytoglobin; May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer | 0.585 |
ALB | HBD | ENSP00000295897 | ENSP00000369654 | albumin | hemoglobin, delta; Involved in oxygen transport from the lung to the various peripheral tissues | 0.428 |
ALB | NAAA | ENSP00000295897 | ENSP00000286733 | albumin | N-acylethanolamine acid amidase; Degrades bioactive fatty acid amides to their corresponding acids, with the following preference- N- palmitoylethanolamine > N-myristoylethanolamine > N- lauroylethanolamine = N-stearoylethanolamine > N- arachidonoylethanolamine > N-oleoylethanolamine. Also exhibits weak hydrolytic activity against the ceramides N- lauroylsphingosine and N-palmitoylsphingosine | 0.418 |
ALB | NOG | ENSP00000295897 | ENSP00000328181 | albumin | noggin; Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite | 0.414 |
ALB | SLC6A3 | ENSP00000295897 | ENSP00000270349 | albumin | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals | 0.418 |
CYGB | ALB | ENSP00000293230 | ENSP00000295897 | cytoglobin; May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer | albumin | 0.585 |
CYGB | DDI1 | ENSP00000293230 | ENSP00000302805 | cytoglobin; May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer | DNA-damage inducible 1 homolog 1 (S. cerevisiae) | 0.603 |
CYGB | HBD | ENSP00000293230 | ENSP00000369654 | cytoglobin; May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer | hemoglobin, delta; Involved in oxygen transport from the lung to the various peripheral tissues | 0.999 |
CYGB | KRT9 | ENSP00000293230 | ENSP00000246662 | cytoglobin; May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer | keratin 9; May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly | 0.606 |
CYGB | NAAA | ENSP00000293230 | ENSP00000286733 | cytoglobin; May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer | N-acylethanolamine acid amidase; Degrades bioactive fatty acid amides to their corresponding acids, with the following preference- N- palmitoylethanolamine > N-myristoylethanolamine > N- lauroylethanolamine = N-stearoylethanolamine > N- arachidonoylethanolamine > N-oleoylethanolamine. Also exhibits weak hydrolytic activity against the ceramides N- lauroylsphingosine and N-palmitoylsphingosine | 0.649 |
CYGB | NGB | ENSP00000293230 | ENSP00000298352 | cytoglobin; May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer | neuroglobin; Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis | 0.905 |
CYGB | NOG | ENSP00000293230 | ENSP00000328181 | cytoglobin; May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer | noggin; Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite | 0.581 |
CYGB | NUDT15 | ENSP00000293230 | ENSP00000258662 | cytoglobin; May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer | nudix (nucleoside diphosphate linked moiety X)-type motif 15; Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8- oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A-T to C-G transversions. Its substrate specificity in vivo however remains unclear (By similarity). May have a role in DNA synthesis and cell cycle progression through the interaction with PCNA | 0.598 |
CYGB | SH3KBP1 | ENSP00000293230 | ENSP00000380921 | cytoglobin; May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer | SH3-domain kinase binding protein 1; Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by intera [...] | 0.572 |
CYGB | SLC6A3 | ENSP00000293230 | ENSP00000270349 | cytoglobin; May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals | 0.647 |
DDI1 | CYGB | ENSP00000302805 | ENSP00000293230 | DNA-damage inducible 1 homolog 1 (S. cerevisiae) | cytoglobin; May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer | 0.603 |
HBD | ALB | ENSP00000369654 | ENSP00000295897 | hemoglobin, delta; Involved in oxygen transport from the lung to the various peripheral tissues | albumin | 0.428 |
HBD | CYGB | ENSP00000369654 | ENSP00000293230 | hemoglobin, delta; Involved in oxygen transport from the lung to the various peripheral tissues | cytoglobin; May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer | 0.999 |
KRT9 | CYGB | ENSP00000246662 | ENSP00000293230 | keratin 9; May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly | cytoglobin; May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer | 0.606 |
NAAA | ALB | ENSP00000286733 | ENSP00000295897 | N-acylethanolamine acid amidase; Degrades bioactive fatty acid amides to their corresponding acids, with the following preference- N- palmitoylethanolamine > N-myristoylethanolamine > N- lauroylethanolamine = N-stearoylethanolamine > N- arachidonoylethanolamine > N-oleoylethanolamine. Also exhibits weak hydrolytic activity against the ceramides N- lauroylsphingosine and N-palmitoylsphingosine | albumin | 0.418 |