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STRINGSTRING
ENSG00000249319 ENSG00000249319 ASL ASL OTC OTC CPS1 CPS1 CAD CAD ASS1 ASS1 NAGS NAGS ALDH18A1 ALDH18A1 GLUD1 GLUD1 GLUD2 GLUD2 ALDH4A1 ALDH4A1
"NAGS" - N-acetylglutamate synthase in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
NAGSN-acetylglutamate synthase; Plays a role in the regulation of ureagenesis by producing variable amounts of N-acetylglutamate (NAG), thus modulating carbamoylphosphate synthase I (CPSI) activity (534 aa)    
Predicted Functional Partners:
ASS1
argininosuccinate synthase 1; Is indirectly involved in the control of blood pressure (By similarity) (412 aa)
score_image     score_image   score_image score_image   0.996
CPS1
carbamoyl-phosphate synthase 1, mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell (1506 aa)
score_image     score_image   score_image score_image   0.986
OTC
ornithine carbamoyltransferase (354 aa)
score_image     score_image     score_image   0.985
CAD
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) (2225 aa)
score_image     score_image   score_image score_image   0.982
ALDH18A1
aldehyde dehydrogenase 18 family, member A1 (795 aa)
score_image         score_image score_image   0.969
ASL
argininosuccinate lyase (464 aa)
score_image     score_image     score_image   0.963
ALDH4A1
aldehyde dehydrogenase 4 family, member A1 (563 aa)
          score_image score_image   0.921
GLUD1
glutamate dehydrogenase 1; May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity) (558 aa)
          score_image score_image   0.913
GLUD2
glutamate dehydrogenase 2; Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission (558 aa)
          score_image score_image   0.907
ENSG00000249319
Uncharacterized protein (293 aa)
score_image     score_image     score_image   0.903
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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