node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CABP2 | GRK5 | ENSP00000294288 | ENSP00000376609 | calcium binding protein 2 | G protein-coupled receptor kinase 5; Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein- coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates- Hsc70- in [...] | 0.743 |
CABP2 | HAND2 | ENSP00000294288 | ENSP00000352565 | calcium binding protein 2 | heart and neural crest derivatives expressed 2; Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and nec [...] | 0.660 |
CABP2 | MYO1G | ENSP00000294288 | ENSP00000258787 | calcium binding protein 2 | myosin IG; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity) | 0.658 |
CABP2 | MYO5A | ENSP00000294288 | ENSP00000382177 | calcium binding protein 2 | myosin VA (heavy chain 12, myoxin); Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation | 0.700 |
CABP2 | MYO5B | ENSP00000294288 | ENSP00000285039 | calcium binding protein 2 | myosin VB; May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis (By similarity) | 0.700 |
CABP2 | MYO5C | ENSP00000294288 | ENSP00000261839 | calcium binding protein 2 | myosin VC; May be involved in transferrin trafficking. Likely to power actin-based membrane trafficking in many physiologically crucial tissues | 0.700 |
CABP2 | OBSCN | ENSP00000294288 | ENSP00000455507 | calcium binding protein 2 | obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF | 0.679 |
CABP2 | POTEF | ENSP00000294288 | ENSP00000350052 | calcium binding protein 2 | POTE ankyrin domain family, member F | 0.634 |
CABP2 | PPP3R1 | ENSP00000294288 | ENSP00000234310 | calcium binding protein 2 | protein phosphatase 3, regulatory subunit B, alpha; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity | 0.657 |
CABP2 | SMOC2 | ENSP00000294288 | ENSP00000346537 | calcium binding protein 2 | SPARC related modular calcium binding 2 | 0.871 |
GRK5 | CABP2 | ENSP00000376609 | ENSP00000294288 | G protein-coupled receptor kinase 5; Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein- coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates- Hsc70- in [...] | calcium binding protein 2 | 0.743 |
HAND2 | CABP2 | ENSP00000352565 | ENSP00000294288 | heart and neural crest derivatives expressed 2; Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and nec [...] | calcium binding protein 2 | 0.660 |
MYO1G | CABP2 | ENSP00000258787 | ENSP00000294288 | myosin IG; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity) | calcium binding protein 2 | 0.658 |
MYO1G | OBSCN | ENSP00000258787 | ENSP00000455507 | myosin IG; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity) | obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF | 0.562 |
MYO1G | POTEF | ENSP00000258787 | ENSP00000350052 | myosin IG; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity) | POTE ankyrin domain family, member F | 0.724 |
MYO5A | CABP2 | ENSP00000382177 | ENSP00000294288 | myosin VA (heavy chain 12, myoxin); Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation | calcium binding protein 2 | 0.700 |
MYO5A | OBSCN | ENSP00000382177 | ENSP00000455507 | myosin VA (heavy chain 12, myoxin); Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation | obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF | 0.631 |
MYO5A | POTEF | ENSP00000382177 | ENSP00000350052 | myosin VA (heavy chain 12, myoxin); Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation | POTE ankyrin domain family, member F | 0.751 |
MYO5B | CABP2 | ENSP00000285039 | ENSP00000294288 | myosin VB; May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis (By similarity) | calcium binding protein 2 | 0.700 |
MYO5B | OBSCN | ENSP00000285039 | ENSP00000455507 | myosin VB; May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis (By similarity) | obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF | 0.659 |