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SUMO2 SUMO2 UBC UBC YIPF1 YIPF1 TRIM63 TRIM63 NCOA2 NCOA2 CREBBP CREBBP GMEB1 GMEB1 UBE2I UBE2I HSPB1 HSPB1 HSPB2 HSPB2 HSPB3 HSPB3
"GMEB1" - glucocorticoid modulatory element binding protein 1 in Homo sapiens
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GMEB1glucocorticoid modulatory element binding protein 1; Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses (573 aa)    
Predicted Functional Partners:
HSPB2
HSPB2-C11orf52 readthrough (non-protein coding); May regulate the kinase DMPK (182 aa)
            score_image   0.933
HSPB3
heat shock 27kDa protein 3; Inhibitor of actin polymerization (150 aa)
            score_image   0.928
HSPB1
heat shock 27kDa protein 1 (205 aa)
            score_image   0.891
TRIM63
tripartite motif containing 63, E3 ubiquitin protein ligase; E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertroph [...] (353 aa)
        score_image   score_image   0.811
UBC
ubiquitin C (685 aa)
        score_image   score_image   0.769
UBE2I
ubiquitin-conjugating enzyme E2I; Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Can catalyze the formation of poly- SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at ’Lys-386’ (By similarity) (158 aa)
        score_image   score_image   0.755
NCOA2
nuclear receptor coactivator 2; Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF- 2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues (1464 aa)
        score_image   score_image   0.712
SUMO2
SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduc [...] (95 aa)
        score_image   score_image   0.688
YIPF1
Yip1 domain family, member 1 (306 aa)
            score_image   0.658
CREBBP
CREB binding protein; Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300 (2442 aa)
        score_image   score_image   0.652
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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