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STRINGSTRING
GDF7 GDF7 DRAXIN DRAXIN NTN1 NTN1 CNTN2 CNTN2
"DRAXIN" - dorsal inhibitory axon guidance protein in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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second shell of interactors
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Predicted Interactions
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protein homology
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DRAXINdorsal inhibitory axon guidance protein; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta- catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway (By similarity) (349 aa)    
Predicted Functional Partners:
NTN1
netrin 1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis (604 aa)
            score_image   0.505
GDF7
growth differentiation factor 7; May play an active role in the motor area of the primate neocortex (By similarity) (450 aa)
            score_image   0.450
CNTN2
contactin 2 (axonal); May play a role in the initial growth and guidance of axons. May be involved in cell adhesion (1040 aa)
            score_image   0.416
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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