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STRINGSTRING
GGA3 GGA3 NEDD4 NEDD4 SDC3 SDC3 ITCH ITCH UBC UBC LAPTM5 LAPTM5 TNFAIP3 TNFAIP3 CD63 CD63 DISP1 DISP1 LAMP1 LAMP1 LAMP2 LAMP2
"LAPTM5" - lysosomal protein transmembrane 5 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
LAPTM5lysosomal protein transmembrane 5; May have a special functional role during embryogenesis and in adult hematopoietic cells (262 aa)    
Predicted Functional Partners:
UBC
ubiquitin C (685 aa)
        score_image       0.945
NEDD4
neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase (1247 aa)
        score_image   score_image   0.845
LAMP1
lysosomal-associated membrane protein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis (417 aa)
      score_image score_image   score_image   0.834
SDC3
syndecan 3; Cell surface proteoglycan that may bear heparan sulfate (By similarity). May have a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism (442 aa)
            score_image   0.749
LAMP2
lysosomal-associated membrane protein 2; Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens (411 aa)
      score_image     score_image   0.703
CD63
CD63 molecule; This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation (238 aa)
            score_image   0.687
TNFAIP3
tumor necrosis factor, alpha-induced protein 3; Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes i [...] (790 aa)
        score_image       0.615
DISP1
dispatched homolog 1 (Drosophila); Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (By similarity) (1524 aa)
        score_image       0.612
ITCH
itchy E3 ubiquitin protein ligase (862 aa)
        score_image   score_image   0.603
GGA3
golgi-associated, gamma adaptin ear containing, ARF binding protein 3; Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif (723 aa)
        score_image   score_image   0.583
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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