node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CD63 | LAMP1 | ENSP00000257857 | ENSP00000333298 | CD63 molecule; This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation | lysosomal-associated membrane protein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis | 0.861 |
CD63 | LAMP2 | ENSP00000257857 | ENSP00000408411 | CD63 molecule; This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation | lysosomal-associated membrane protein 2; Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens | 0.831 |
CD63 | LAPTM5 | ENSP00000257857 | ENSP00000294507 | CD63 molecule; This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation | lysosomal protein transmembrane 5; May have a special functional role during embryogenesis and in adult hematopoietic cells | 0.687 |
CD63 | UBC | ENSP00000257857 | ENSP00000344818 | CD63 molecule; This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation | ubiquitin C | 0.909 |
DISP1 | LAPTM5 | ENSP00000284476 | ENSP00000294507 | dispatched homolog 1 (Drosophila); Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (By similarity) | lysosomal protein transmembrane 5; May have a special functional role during embryogenesis and in adult hematopoietic cells | 0.612 |
GGA3 | ITCH | ENSP00000245541 | ENSP00000363998 | golgi-associated, gamma adaptin ear containing, ARF binding protein 3; Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif | itchy E3 ubiquitin protein ligase | 0.643 |
GGA3 | LAPTM5 | ENSP00000245541 | ENSP00000294507 | golgi-associated, gamma adaptin ear containing, ARF binding protein 3; Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif | lysosomal protein transmembrane 5; May have a special functional role during embryogenesis and in adult hematopoietic cells | 0.583 |
GGA3 | NEDD4 | ENSP00000245541 | ENSP00000345530 | golgi-associated, gamma adaptin ear containing, ARF binding protein 3; Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.715 |
GGA3 | UBC | ENSP00000245541 | ENSP00000344818 | golgi-associated, gamma adaptin ear containing, ARF binding protein 3; Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif | ubiquitin C | 0.999 |
ITCH | GGA3 | ENSP00000363998 | ENSP00000245541 | itchy E3 ubiquitin protein ligase | golgi-associated, gamma adaptin ear containing, ARF binding protein 3; Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif | 0.643 |
ITCH | LAPTM5 | ENSP00000363998 | ENSP00000294507 | itchy E3 ubiquitin protein ligase | lysosomal protein transmembrane 5; May have a special functional role during embryogenesis and in adult hematopoietic cells | 0.603 |
ITCH | TNFAIP3 | ENSP00000363998 | ENSP00000237289 | itchy E3 ubiquitin protein ligase | tumor necrosis factor, alpha-induced protein 3; Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes i [...] | 0.903 |
ITCH | UBC | ENSP00000363998 | ENSP00000344818 | itchy E3 ubiquitin protein ligase | ubiquitin C | 0.999 |
LAMP1 | CD63 | ENSP00000333298 | ENSP00000257857 | lysosomal-associated membrane protein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis | CD63 molecule; This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation | 0.861 |
LAMP1 | LAPTM5 | ENSP00000333298 | ENSP00000294507 | lysosomal-associated membrane protein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis | lysosomal protein transmembrane 5; May have a special functional role during embryogenesis and in adult hematopoietic cells | 0.834 |
LAMP1 | TNFAIP3 | ENSP00000333298 | ENSP00000237289 | lysosomal-associated membrane protein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis | tumor necrosis factor, alpha-induced protein 3; Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes i [...] | 0.585 |
LAMP1 | UBC | ENSP00000333298 | ENSP00000344818 | lysosomal-associated membrane protein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis | ubiquitin C | 0.644 |
LAMP2 | CD63 | ENSP00000408411 | ENSP00000257857 | lysosomal-associated membrane protein 2; Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens | CD63 molecule; This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation | 0.831 |
LAMP2 | LAPTM5 | ENSP00000408411 | ENSP00000294507 | lysosomal-associated membrane protein 2; Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens | lysosomal protein transmembrane 5; May have a special functional role during embryogenesis and in adult hematopoietic cells | 0.703 |
LAPTM5 | CD63 | ENSP00000294507 | ENSP00000257857 | lysosomal protein transmembrane 5; May have a special functional role during embryogenesis and in adult hematopoietic cells | CD63 molecule; This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation | 0.687 |