PKDCC protein (Homo sapiens) - STRING network view

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PKDCC

protein kinase domain containing, cytoplasmic homolog (mouse); Protein kinase which is required for longitudinal bone growth through regulation of chondrocyte differentiation. Involved in protein transport from the Golgi apparatus to the plasma membrane (By similarity) (493 aa)

Predicted Functional Partners:

PHLPP2

0.788

PHLPP1

0.788

LRGUK

0.688

PPM1L

0.643

PPM1N

0.643

PDP1

0.643

PP2D1

0.643

PPTC7

0.643

PPM1A

0.643

PPM1E

0.643

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LRGUK	PDP1	ENSP00000285928	ENSP00000379503	leucine-rich repeats and guanylate kinase domain containing	pyruvate dehyrogenase phosphatase catalytic subunit 1; Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (By similarity)	0.621
LRGUK	PHLPP1	ENSP00000285928	ENSP00000262719	leucine-rich repeats and guanylate kinase domain containing	PH domain and leucine rich repeat protein phosphatase 1; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads [...]	0.665
LRGUK	PHLPP2	ENSP00000285928	ENSP00000348611	leucine-rich repeats and guanylate kinase domain containing	PH domain and leucine rich repeat protein phosphatase 2; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradati [...]	0.665
LRGUK	PKDCC	ENSP00000285928	ENSP00000294964	leucine-rich repeats and guanylate kinase domain containing	protein kinase domain containing, cytoplasmic homolog (mouse); Protein kinase which is required for longitudinal bone growth through regulation of chondrocyte differentiation. Involved in protein transport from the Golgi apparatus to the plasma membrane (By similarity)	0.688
LRGUK	PP2D1	ENSP00000285928	ENSP00000373702	leucine-rich repeats and guanylate kinase domain containing	protein phosphatase 2C-like domain containing 1	0.621
LRGUK	PPM1A	ENSP00000285928	ENSP00000327255	leucine-rich repeats and guanylate kinase domain containing	protein phosphatase, Mg2+/Mn2+ dependent, 1A; Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling	0.621
LRGUK	PPM1E	ENSP00000285928	ENSP00000312411	leucine-rich repeats and guanylate kinase domain containing	protein phosphatase, Mg2+/Mn2+ dependent, 1E; Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42	0.621
LRGUK	PPM1L	ENSP00000285928	ENSP00000417659	leucine-rich repeats and guanylate kinase domain containing	protein phosphatase, Mg2+/Mn2+ dependent, 1L; Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6	0.621
LRGUK	PPM1N	ENSP00000285928	ENSP00000397050	leucine-rich repeats and guanylate kinase domain containing	protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative)	0.621
LRGUK	PPTC7	ENSP00000285928	ENSP00000346255	leucine-rich repeats and guanylate kinase domain containing	PTC7 protein phosphatase homolog (S. cerevisiae)	0.621
PDP1	LRGUK	ENSP00000379503	ENSP00000285928	pyruvate dehyrogenase phosphatase catalytic subunit 1; Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (By similarity)	leucine-rich repeats and guanylate kinase domain containing	0.621
PDP1	PKDCC	ENSP00000379503	ENSP00000294964	pyruvate dehyrogenase phosphatase catalytic subunit 1; Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (By similarity)	protein kinase domain containing, cytoplasmic homolog (mouse); Protein kinase which is required for longitudinal bone growth through regulation of chondrocyte differentiation. Involved in protein transport from the Golgi apparatus to the plasma membrane (By similarity)	0.643
PDP1	PP2D1	ENSP00000379503	ENSP00000373702	pyruvate dehyrogenase phosphatase catalytic subunit 1; Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (By similarity)	protein phosphatase 2C-like domain containing 1	0.552
PDP1	PPM1A	ENSP00000379503	ENSP00000327255	pyruvate dehyrogenase phosphatase catalytic subunit 1; Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (By similarity)	protein phosphatase, Mg2+/Mn2+ dependent, 1A; Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling	0.622
PDP1	PPM1E	ENSP00000379503	ENSP00000312411	pyruvate dehyrogenase phosphatase catalytic subunit 1; Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (By similarity)	protein phosphatase, Mg2+/Mn2+ dependent, 1E; Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42	0.563
PDP1	PPTC7	ENSP00000379503	ENSP00000346255	pyruvate dehyrogenase phosphatase catalytic subunit 1; Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (By similarity)	PTC7 protein phosphatase homolog (S. cerevisiae)	0.708
PHLPP1	LRGUK	ENSP00000262719	ENSP00000285928	PH domain and leucine rich repeat protein phosphatase 1; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads [...]	leucine-rich repeats and guanylate kinase domain containing	0.665
PHLPP1	PHLPP2	ENSP00000262719	ENSP00000348611	PH domain and leucine rich repeat protein phosphatase 1; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads [...]	PH domain and leucine rich repeat protein phosphatase 2; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradati [...]	0.999
PHLPP1	PKDCC	ENSP00000262719	ENSP00000294964	PH domain and leucine rich repeat protein phosphatase 1; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads [...]	protein kinase domain containing, cytoplasmic homolog (mouse); Protein kinase which is required for longitudinal bone growth through regulation of chondrocyte differentiation. Involved in protein transport from the Golgi apparatus to the plasma membrane (By similarity)	0.788
PHLPP2	LRGUK	ENSP00000348611	ENSP00000285928	PH domain and leucine rich repeat protein phosphatase 2; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradati [...]	leucine-rich repeats and guanylate kinase domain containing	0.665

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