node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BBOX1 | TRAT1 | ENSP00000263182 | ENSP00000295756 | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1; Catalyzes the formation of L-carnitine from gamma- butyrobetaine | T cell receptor associated transmembrane adaptor 1; Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells | 0.825 |
BBOX1 | TRIM17 | ENSP00000263182 | ENSP00000295033 | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1; Catalyzes the formation of L-carnitine from gamma- butyrobetaine | tripartite motif containing 17; May function as an ubiquitin E3 ligase | 0.824 |
BBOX1 | TRIM44 | ENSP00000263182 | ENSP00000299413 | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1; Catalyzes the formation of L-carnitine from gamma- butyrobetaine | tripartite motif containing 44; May play a role in the process of differentiation and maturation of neuronal cells (By similarity). May regulate the activity of TRIM17 | 0.561 |
BBOX1 | TRIM67 | ENSP00000263182 | ENSP00000355613 | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1; Catalyzes the formation of L-carnitine from gamma- butyrobetaine | tripartite motif containing 67 | 0.608 |
BBOX1 | TRIM9 | ENSP00000263182 | ENSP00000298355 | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1; Catalyzes the formation of L-carnitine from gamma- butyrobetaine | tripartite motif containing 9; E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions and may also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorders. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation | 0.744 |
MCL1 | TRIM17 | ENSP00000358022 | ENSP00000295033 | myeloid cell leukemia sequence 1 (BCL2-related) | tripartite motif containing 17; May function as an ubiquitin E3 ligase | 0.838 |
MCL1 | UBC | ENSP00000358022 | ENSP00000344818 | myeloid cell leukemia sequence 1 (BCL2-related) | ubiquitin C | 0.999 |
TRAT1 | BBOX1 | ENSP00000295756 | ENSP00000263182 | T cell receptor associated transmembrane adaptor 1; Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1; Catalyzes the formation of L-carnitine from gamma- butyrobetaine | 0.825 |
TRAT1 | TRIM17 | ENSP00000295756 | ENSP00000295033 | T cell receptor associated transmembrane adaptor 1; Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells | tripartite motif containing 17; May function as an ubiquitin E3 ligase | 0.820 |
TRAT1 | TRIM9 | ENSP00000295756 | ENSP00000298355 | T cell receptor associated transmembrane adaptor 1; Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells | tripartite motif containing 9; E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions and may also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorders. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation | 0.660 |
TRIM17 | BBOX1 | ENSP00000295033 | ENSP00000263182 | tripartite motif containing 17; May function as an ubiquitin E3 ligase | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1; Catalyzes the formation of L-carnitine from gamma- butyrobetaine | 0.824 |
TRIM17 | MCL1 | ENSP00000295033 | ENSP00000358022 | tripartite motif containing 17; May function as an ubiquitin E3 ligase | myeloid cell leukemia sequence 1 (BCL2-related) | 0.838 |
TRIM17 | TRAT1 | ENSP00000295033 | ENSP00000295756 | tripartite motif containing 17; May function as an ubiquitin E3 ligase | T cell receptor associated transmembrane adaptor 1; Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells | 0.820 |
TRIM17 | TRIM44 | ENSP00000295033 | ENSP00000299413 | tripartite motif containing 17; May function as an ubiquitin E3 ligase | tripartite motif containing 44; May play a role in the process of differentiation and maturation of neuronal cells (By similarity). May regulate the activity of TRIM17 | 0.917 |
TRIM17 | TRIM67 | ENSP00000295033 | ENSP00000355613 | tripartite motif containing 17; May function as an ubiquitin E3 ligase | tripartite motif containing 67 | 0.752 |
TRIM17 | TRIM9 | ENSP00000295033 | ENSP00000298355 | tripartite motif containing 17; May function as an ubiquitin E3 ligase | tripartite motif containing 9; E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions and may also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorders. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation | 0.677 |
TRIM17 | UBC | ENSP00000295033 | ENSP00000344818 | tripartite motif containing 17; May function as an ubiquitin E3 ligase | ubiquitin C | 0.810 |
TRIM17 | UBE2D1 | ENSP00000295033 | ENSP00000363019 | tripartite motif containing 17; May function as an ubiquitin E3 ligase | ubiquitin-conjugating enzyme E2D 1; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys- 48’-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyu [...] | 0.740 |
TRIM17 | UBE2D2 | ENSP00000295033 | ENSP00000381717 | tripartite motif containing 17; May function as an ubiquitin E3 ligase | ubiquitin-conjugating enzyme E2D 2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys- 11’-, as well as ’Lys-48’-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions ’Lys-21’ and/or ’Lys-22’ with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-prime [...] | 0.722 |
TRIM17 | ZWINT | ENSP00000295033 | ENSP00000363055 | tripartite motif containing 17; May function as an ubiquitin E3 ligase | ZW10 interactor; Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase | 0.916 |