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SPATA21 SPATA21 SEC31B SEC31B PDCD6IP PDCD6IP CAPN13 CAPN13 PTPN23 PTPN23 HMP70 HMP70 SEC31A SEC31A CHMP4B CHMP4B RHPN2 RHPN2 RHPN1 RHPN1 CHMP4C CHMP4C
"CAPN13" - calpain 13 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CAPN13calpain 13; Probable non-lysosomal thiol-protease (By similarity) (669 aa)    
Predicted Functional Partners:
CHMP4C
charged multivesicular body protein 4C; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] (233 aa)
        score_image   score_image   0.816
HMP70
Transmembrane 9 superfamily member 1 ; Plays an essential role in autophagy (815 aa)
        score_image   score_image   0.801
CHMP4B
charged multivesicular body protein 4B; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] (224 aa)
        score_image   score_image   0.794
SEC31B
SEC31 homolog B (S. cerevisiae); As a component of the coat protein complex II (COPII), may function in vesicle budding and cargo export from the endoplasmic reticulum (1179 aa)
        score_image   score_image   0.752
SEC31A
SEC31 homolog A (S. cerevisiae) (1220 aa)
        score_image   score_image   0.752
PTPN23
protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis (1636 aa)
        score_image   score_image   0.699
PDCD6IP
programmed cell death 6 interacting protein; Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such [...] (873 aa)
        score_image   score_image   0.686
RHPN1
rhophilin, Rho GTPase binding protein 1; Has no enzymatic activity. May serve as a target for Rho, and interact with some cytoskeletal component upon Rho binding or relay a Rho signal to other molecules (By similarity) (670 aa)
        score_image   score_image   0.686
RHPN2
rhophilin, Rho GTPase binding protein 2; Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity (686 aa)
        score_image   score_image   0.686
SPATA21
spermatogenesis associated 21; Involved in the differentiation of haploid spermatids (By similarity) (469 aa)
            score_image   0.635
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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