ARL5A protein (Homo sapiens) - STRING network view

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ARL5A

ADP-ribosylation factor-like 5A; Lacks ADP-ribosylation enhancing activity (By similarity) (179 aa)

Predicted Functional Partners:

GBF1

0.642

ENSG00000262633

0.636

GOSR2

0.636

ARFGAP3

0.624

AGFG1

0.623

ACLY

0.621

ARFGAP2

0.615

NMT1

0.608

RAB1B

0.601

RAB25

0.586

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACLY	ARL5A	ENSP00000253792	ENSP00000295087	ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine	ADP-ribosylation factor-like 5A; Lacks ADP-ribosylation enhancing activity (By similarity)	0.621
ACLY	RAB25	ENSP00000253792	ENSP00000354376	ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine	RAB25, member RAS oncogene family; Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia. Increases the rates of ovarian and breast cancers progression and aggressiveness by modulating cellular processes such as proliferation, survival and migration of epithelial tumor cells. May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis (By similarity)	0.621
AGFG1	ARL5A	ENSP00000387282	ENSP00000295087	ArfGAP with FG repeats 1	ADP-ribosylation factor-like 5A; Lacks ADP-ribosylation enhancing activity (By similarity)	0.623
AGFG1	RAB1B	ENSP00000387282	ENSP00000310226	ArfGAP with FG repeats 1	RAB1B, member RAS oncogene family; Protein transport. Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments	0.461
AGFG1	RAB25	ENSP00000387282	ENSP00000354376	ArfGAP with FG repeats 1	RAB25, member RAS oncogene family; Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia. Increases the rates of ovarian and breast cancers progression and aggressiveness by modulating cellular processes such as proliferation, survival and migration of epithelial tumor cells. May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis (By similarity)	0.435
ARFGAP2	ARL5A	ENSP00000434442	ENSP00000295087	ADP-ribosylation factor GTPase activating protein 2; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes	ADP-ribosylation factor-like 5A; Lacks ADP-ribosylation enhancing activity (By similarity)	0.615
ARFGAP2	ENSG00000262633	ENSP00000434442	ENSP00000461460	ADP-ribosylation factor GTPase activating protein 2; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes	Golgi SNAP receptor complex member 2; Uncharacterized protein	0.767
ARFGAP2	GBF1	ENSP00000434442	ENSP00000359000	ADP-ribosylation factor GTPase activating protein 2; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes	golgi brefeldin A resistant guanine nucleotide exchange factor 1; Promotes guanine-nucleotide exchange on ARF5. Promotes the activation of ARF5 through replacement of GDP with GTP (By similarity)	0.459
ARFGAP2	GOSR2	ENSP00000434442	ENSP00000225567	ADP-ribosylation factor GTPase activating protein 2; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes	golgi SNAP receptor complex member 2; Involved in transport of proteins from the cis/medial- Golgi to the trans-Golgi network	0.767
ARFGAP3	ARL5A	ENSP00000263245	ENSP00000295087	ADP-ribosylation factor GTPase activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes	ADP-ribosylation factor-like 5A; Lacks ADP-ribosylation enhancing activity (By similarity)	0.624
ARFGAP3	ENSG00000262633	ENSP00000263245	ENSP00000461460	ADP-ribosylation factor GTPase activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes	Golgi SNAP receptor complex member 2; Uncharacterized protein	0.772
ARFGAP3	GBF1	ENSP00000263245	ENSP00000359000	ADP-ribosylation factor GTPase activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes	golgi brefeldin A resistant guanine nucleotide exchange factor 1; Promotes guanine-nucleotide exchange on ARF5. Promotes the activation of ARF5 through replacement of GDP with GTP (By similarity)	0.460
ARFGAP3	GOSR2	ENSP00000263245	ENSP00000225567	ADP-ribosylation factor GTPase activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes	golgi SNAP receptor complex member 2; Involved in transport of proteins from the cis/medial- Golgi to the trans-Golgi network	0.775
ARL5A	ACLY	ENSP00000295087	ENSP00000253792	ADP-ribosylation factor-like 5A; Lacks ADP-ribosylation enhancing activity (By similarity)	ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine	0.621
ARL5A	AGFG1	ENSP00000295087	ENSP00000387282	ADP-ribosylation factor-like 5A; Lacks ADP-ribosylation enhancing activity (By similarity)	ArfGAP with FG repeats 1	0.623
ARL5A	ARFGAP2	ENSP00000295087	ENSP00000434442	ADP-ribosylation factor-like 5A; Lacks ADP-ribosylation enhancing activity (By similarity)	ADP-ribosylation factor GTPase activating protein 2; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes	0.615
ARL5A	ARFGAP3	ENSP00000295087	ENSP00000263245	ADP-ribosylation factor-like 5A; Lacks ADP-ribosylation enhancing activity (By similarity)	ADP-ribosylation factor GTPase activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes	0.624
ARL5A	ENSG00000262633	ENSP00000295087	ENSP00000461460	ADP-ribosylation factor-like 5A; Lacks ADP-ribosylation enhancing activity (By similarity)	Golgi SNAP receptor complex member 2; Uncharacterized protein	0.636
ARL5A	GBF1	ENSP00000295087	ENSP00000359000	ADP-ribosylation factor-like 5A; Lacks ADP-ribosylation enhancing activity (By similarity)	golgi brefeldin A resistant guanine nucleotide exchange factor 1; Promotes guanine-nucleotide exchange on ARF5. Promotes the activation of ARF5 through replacement of GDP with GTP (By similarity)	0.642
ARL5A	GOSR2	ENSP00000295087	ENSP00000225567	ADP-ribosylation factor-like 5A; Lacks ADP-ribosylation enhancing activity (By similarity)	golgi SNAP receptor complex member 2; Involved in transport of proteins from the cis/medial- Golgi to the trans-Golgi network	0.636

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